Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.


Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature (2016).
Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated New and Views.

See our latest ANP32 papers here: eLIFE, Journal of Virology, Journal of Virology.


The mechanism of resistance to favipiravir in influenza. PNAS (2018).
Daniel H. GoldhillAartjan J. W. te VelthuisRobert A. FletcherPinky LangatMaria ZambonAngie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.


Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice. Plos Path. (2018).
Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.


Citation

BibTex format

@article{George:2021:10.1177/01945998211004255,
author = {George, MM and McIntyre, CJ and Zhou, J and Kugathasan, R and Amos, DC and Dillon, IJ and Barclay, WS and Tolley, NS},
doi = {10.1177/01945998211004255},
journal = {OTOLARYNGOLOGY-HEAD AND NECK SURGERY},
pages = {819--826},
title = {Viral Infectivity in Patients Undergoing Tracheotomy With COVID-19: A Preliminary Study},
url = {http://dx.doi.org/10.1177/01945998211004255},
volume = {165},
year = {2021}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AU - George,MM
AU - McIntyre,CJ
AU - Zhou,J
AU - Kugathasan,R
AU - Amos,DC
AU - Dillon,IJ
AU - Barclay,WS
AU - Tolley,NS
DO - 10.1177/01945998211004255
EP - 826
PY - 2021///
SN - 0194-5998
SP - 819
TI - Viral Infectivity in Patients Undergoing Tracheotomy With COVID-19: A Preliminary Study
T2 - OTOLARYNGOLOGY-HEAD AND NECK SURGERY
UR - http://dx.doi.org/10.1177/01945998211004255
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000682617100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL - 165
ER -