Tissue Engineering and Regenerative Medicine (UG)

Module aims

This module will introduce fundamental concepts of normal tissue development, then discuss how researchers have used this information to imitate nature in a lab setting, engineering cells and tissues that may be used to model diseases, treat disease, or develop drugs.

Learning outcomes

Define cell building blocks, and be able to explain how these building blocks are composed to make cells with different functions; Recognise how single amino acid changes can alter protein, and subsequently cell function; Explain why different cell types are required in different tissues; Recall methods for generating induced pluripotent stem cells; Describe stem cell differentiation techniques, and identify how these protocols were developed (imitating nature); Express where cell and tissue therapy are beneficial; Discuss the implications of gene therapy; Describe how tissue engineering can be beneficial in drug development; Propose tissue engineering solutions for different diseases; Design experimental protocols, and know the plan of action if a blood sample, or tissue biopsy is sent to the lab for a particular disease.

Module syllabus

Societal challenges for tissue engineering Cell building blocks Normal tissue development and regeneration Adult stem cells -Induced pluripotent stem cells Challenges in imitating nature Cell and tissue therapy Gene therapy Drug development -Bench to bedside challenges

Pre-requisites

 BE1-HCMP Molecules, cells and processes BE1-HMS1 Medical Science 1 BE2-HMS2 Medical Science 2 

Teaching methods

Students will be taught over one term using a combination of lectures and study groups. Lecture sessions will be made available on Panopto for review and supplemented with technologies as appropriate to promote active engagement during the lecture such as 'learning catalytics'. Study groups will be based on taught content from lectures to reinforce these topics and allow students to test their understanding.

Lectures: 18 hours

Tutorials: 10 hours  

Assessments

Overall performance against all LOs in the module will be assessed by a 90 minute final exam, 6 questions, 100% weighting