Cellular and Molecular Mechanotransduction (PG)

Module aims

Topics include: Introduction to Mechanobiology; The cytoskeleton in cells; Main molecular signalling pathways involved in cell biomechanics; Subcellular structures and molecules relevant to mechanobiology; Mechanosensing, mechanotransduction, and mechanosignalling; Techniques for mechanical manipulation of cells; Mechanotransduction across different length scales; Cellular mechanotransduction; Molecular mechanotransduction; Mechanotransduction in health and disease; Biomechanics of stem cells; Biomechanics of pancreatic cancer; Biomechanics of liver cancer; Biomechanics of breast cancer.

Learning outcomes

    To understand the basic concepts of mechanotransduction in biology; To understand mechanotransduction across several levels of organisation in physiological and pathological processes; To describe basic principles of techniques used in biomechanics research; To analyse/discuss cellular processes from a biomechanical perspective; To evaluate the advantages and disadvantages of current techniques used to mechanically manipulate cells and molecules; To evaluate the utility of biomechanical models to understand cell and tissue structure and function; Understand how mechanical forces affect the functions of molecules and cells; To deliver clear written communication; To develop skills in critical reading of scientific literature.

Module syllabus

Topics included: Introduction to Mechanobiology; The cytoskeleton in cells; Main molecular signalling pathways involved in cell biomechanics; Subcellular structures and molecules relevant to mechanobiology; Mechanosensing, mechanotransduction, and mechanosignalling; Techniques for mechanical manipulation of cells; Mechanotransduction across different length scales; Cellular mechanotransduction; Molecular mechanotransduction; Mechanotransduction in health and disease; Biomechanics of stem cells; Biomechanics of pancreatic cancer; Biomechanics of liver cancer; Biomechanics of breast cancer.

Teaching methods

Teaching Methods
Lectures: 12 hours
Workshop: 13 hours
Tutorials: 11 hours

 

Assessments

Examinations:
●  Written exam: ; 100% weighting
    Rubrics: Final exam will include 3 compulsory questions. All questions must be answered. Weighting 100%. 2h duration.
    No type of previous exam answers or solutions will be available

Feedback : Feedback given immediately during study groups.Overall performance against all LOs in the module will be assessed by a final exam in the summer term.

Reading list