Medical and Biochemical Science 2

Module aims

 In this module you will build on your knowledge from Medical and Biochemical Science 1 module, and be introduced to new cellular and physiological concepts. The module aims to introduce you to further physiological systems with a strong emphasis on the nervous system and to introduce you to regulators and modulators of gene expression, i.e. genetics and epigenetics, with a specific focus on methylation. The module will also allow you to build competence with new wet lab skills and allow you to gain familiarity with a range of lab techniques that may be required in final year projects.

Learning outcomes

 Upon successful completion of this module you will be able to: Discuss and explain the complexity of biological control systems and the physiological and structural constraints under which they operate. Distinguish between general principles and specific adaptations in biological control systems. Relate anatomical structures and physiological mechanisms to the functional organisation of biological systems. Discuss and explain the design constraints of biological systems. Recognise the role of the environment in mediating epigenetic changes Distinguish between epigenetic modifications which can alter gene expression Analyse and interpret different forms of sequencing data Show proficiency in a range of wet labs techniques

Module syllabus

 In this module you will cover the following topics: Medical Science: Human Nervous System, Musculoskeletal System, Endocrine System, Gastrointestinal System, Human Reproductive System and Renal System Molecules, cells and processes: Cell building blocks/DNA packing Transcription. Primer design to assess transcription Promotors, enhancers, transcription factor binding. Epigenetic mechanisms-chromatin/histone marks Epigenetic mechanisms-Methylation. X inactivation. Bisulfite sequencing. Genomic imprinting Epigenetic clock-aging Epigenetic drugs

Teaching methods

  • Medical Science 2 : 18 Lectures, 9 study groups
  • MCP2 : 18 Lectures, 9 study groups, labs
  • Arduino : lab

Assessments

  • Medical Science 2 : Mastery 13.3%, non-mastery 20%
  • MCP2 : lab report 25%, written exam 25%
  • Arduino : presentation 16.7%