Advanced Imaging Technologies for Systems Biology (UG)
In this module you will be introduced to advanced imaging technologies as a powerful toolbox in systems biology with an emphasis on addressing developmental and disease processes in various animal models. The overall goal of the module is to enable you to critically evaluate and carefully design imaging experiments in order to analyse dynamic processes in complex biological systems.
Upon succesful completion of this module you will be able to:
Explain and compare various imaging techniques
Describe different approaches of image processing such as 3D-reconstruction, image restoration, and analysis
Discuss the advantages of various model organisms for systems biology studies
Explain developmental principles during animal development
Imaging offers the unique advantage of observing biological processes with high spatiotemporal resolution in whole organisms, offering a path to more refined, quantitative dynamic models. The recent introduction of advanced imaging tools and automated instrumentation will enable researchers to apply imaging for both hypothesis-driven research and high-throughput analysis
To achieve such biosystems imaging expertise, you will need to acquire following four competences:
a) identify and compare various imaging techniques. This competence will be accomplished by giving you an in-depth view of modern microscopy techniques such as confocal, non-linear, and fast volumetric microscopy. Further, the student will be introduced into quantitative fluorescence microscopy techniques that have been successfully conducted in the laboratory (e.g. FRAP, FDAP).
b) describe different approaches to image processing such as 3D-reconstruction, image restoration, and analysis. These approached will allow you to take full advantage of the information within the data generated by the techniques within (a).
c) discuss the advantages of various model organisms for systems biology studies. The emphasis here will be on the relevance and quality of the data whilst conducting animal experiments with the highest ethical standards.
d) Explain developmental principles during animal development such as emergence of asymmetry, pattern formation and regeneration.
With these competences at hand, you will appreciate how to exploit advanced imaging technologies as a particularly valuable toolbox capable of elucidating dynamic processes in complex biological systems. You will be able to evaluate different experimental approaches to interrogate development and disease, and test hypotheses by designing imaging experiments to analyse dynamic biological processes.
Students will be taught over one term using a combination of lectures and group teaching. Lecture sessions will be made available on Panopto for review and supplemented with technologies to promote active engagement during the lecture such as 'learning catalytics'. There will also be group discussions based on taught content from lectures to reinforce these topics and allow students to test their understanding.
The module will be assessed by a group presentation and a final exam.
Written exam 100%