Nanotechnologies for cancer diagnosis and cancer therapy

Module aims

This module will introduce you to the latest nanotechnological advances in the field of cancer diagnostics and cancer therapies. This course will show how academic research can lead to applied science with direct impact on the way cancer patients are screened, diagnosed, monitored and treated. In particular, you will learn how molecular bioengineering has applications in the following fields: - Development of minimally invasive screening tools (e.g. based on liquid biopsies) - Diagnosis at the point of care (low-cost, automated technologies) - Nanotechnologies for targeted drug delivery - Novel therapeutic approaches for Cancer

Learning outcomes

Upon successful completion of this module you will be able to: - Explain how diagnostic tests or screening tools are designed and engineered that can detect specific cancer biomarkers in tissues, cells or circulating bodily fluids - Assess whether a newly engineered technology is fit-for-purpose - Describe how small molecules, macromolecules and biomaterials can be engineered to target cancer cells - Understand the concepts of off-target effects and how they can be minimised using targeted therapies - Summarize and critically analyse the state of the art of engineered solutions for early detection and improved prognosis of cancer (e.g. via public screening of populations at risk; using more targeted drugs or drug delivery strategies) - write a research proposal to a professional standard that addresses a current medical need

Module syllabus

Introduction to cancer biomarkers -Engineering a new diagnostic test: from molecular recogntition to sensing device -Technical and clinical validation of new diagnostic technologies -Platform technologies and point-of-care devices for cancer diagnosiss -Engineering new therapies for cancer -Nanotechnologies for targeted drug delivery -2D and 3D in vitro models in cancer research

Assessments

Written exam 60%

Report 40%