My PhD research involves scale-resolving CFD simulations of patient-specific aortas with aortic valve disease and different aortic valve prostheses. We use MRI imaging data to reconstruct patient geometries and provide physiological boundary conditions. This research focuses primarily on laminar-to-turbulence transition with the aim of understanding the effects of turbulence on aortic haemodynamics and biomechanics.
My second research theme aims to improve treatments for acute ischaemic stroke. We are working closely with clinicians to investigate combined intravenous thrombolysis and mechanical thrombectomy treatments using a multi-scale model of thrombolysis which incorporates blood flow, drug transport and species reactions.
I completed my undergraduate studies in Mathematics at The University of Sheffield, where I developed an interest in fluid mechanics and continued my studies with an MSc in Mechanical Engineering at Cranfield University. The following two years I worked as a CFD Engineer for a leading consultancy company where I gained extensive experience with aerodynamic analysis, development and optimisation of high performance race cars.
October 2017 - Present
PhD in Chemical Engineering, Imperial College London
2015 - 2017
Computational Fluid Dynamics Engineer, TotalSim, Brackley UK
2014 - 2015
MSc Advanced Mechanical Engineering, Cranfield University
2011 - 2014
BSc in Mathematics, University of Sheffield
My research interests primarily include fluid mechanics and numerical modelling, with a focus on transitional and turbulent flows. My research project involves patient-specific numerical modelling of the aorta of patient’s having undergone aortic valve replacement. This research pays particular attention to transitional modelling, analysing the influence of different valves on laminar to turbulence transition. Numerical models include computational fluid dynamics and fluid-structure interactions, with results used to improve current prosthesis designs and develop new options.
"Understanding the effects of turbulence and transition in patients with aortic valve disease and different aortic valve prostheses".
Prof Xiao Yun Xu
Department of Chemical Engineering, Imperial College London, UK
Manchester E.L., Roi D, Gu B, Xu XY, Lobotesis K. Modelling Combined Intravenous Thrombolysis and Mechanical Thrombectomy in Acute Ischaemic Stroke: Understanding the Relationship between Stent Retriever Configuration and Clot Lysis Mechanisms. Life (2021); 11(11):1271. https://doi.org/10.3390/life11111271
Manchester E.L., S. Pirola, M.Y. Salmasi, D.P. O'Regan, T. Athanasiou, X.Y. Xu. Analysis of turbulence effects in a patient-specific aorta with aortic valve stenosis. Cardiovascular Engineering and Technology (2021). https://doi.org/10.1007/s13239-021-00536-9
Manchester E.L., X.Y. Xu. The effect of turbulence on transitional flow in the FDA's benchmark nozzle model using large-eddy simulation. Int J Numer Meth Biomed Engng (2020); e3389. https://doi.org/10.1002/cnm.3389
Awards and Funding
Fully funded PhD scholarship awarded by the Department of Chemical Engineering, Imperial College London.
“Aerospace MSc Bursary” awarded The Royal Academy of Engineering and The Royal Aeronautical Society
ACEX 1M17, Department of Chemical Engineering
Imperial College London, South Kensington Campus
London, SW7 2AZ, UK
+44 (0)207 594 2562