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  • Conference paper
    Cheong PL, Bourne M, Griffith TM, Xu XYet al., 2004,

    Comparison of in vivo MRI measurements with numerical predictions

    , Calgary, 2nd IASTED international conference on biomedical engineering, Innsburck, Austria, 16 - 18 February 2004, Publisher: Acta Press, Pages: 78-82
  • Conference paper
    Merrifield R, Long Q, Xu X, Kilner P, Firmin D, Yang Get al., 2004,

    Combined CFD/MRI Analysis of Left Ventricular Flow

    , MIAR 2003, Pages: 229-236
  • Journal article
    Leung J, Wright A, Cheshire N, Thom SA, Hughes AD, Xu XYet al., 2004,

    Flow patterns and wall shear stresses in patient-specific models of the abdominal aortic aneurysm.

    , Stud Health Technol Inform, Vol: 103, Pages: 235-242, ISSN: 0926-9630

    Abdominal Aortic Aneurysms (AAAs) are a major cause of death in Western societies. However, the factors responsible for the growth and ultimate rupture of AAA are not fully understood. Using computation fluid dynamics combined with CT images, the flow patterns and wall shear stress (WSS) in the AAA of a patient were studied. AAA geometry was obtained from images acquired during a routine CT scan, and a realistic abdominal aortic flow waveform was used as an upstream boundary condition. The computational results showed the presence of multiple flow recirculation zones and overall low WSS in the bulge of the aneurysm. This may provide some insight into the growth of thrombus in AAA.

  • Journal article
    Long Q, Merrifield R, Yang GZ, Kilner PJ, Firmin DN, Xu XYet al., 2003,

    The influence of inflow boundary conditions on intra left ventricle flow predictions

    , JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 125, Pages: 922-927, ISSN: 0148-0731
  • Journal article
    Glor FP, Ariff B, Crowe LA, Hughes AD, Cheong PL, Thom SAM, Verdonck PR, Firmin DN, Barratt DC, Xu XYet al., 2003,

    Carotid geometry reconstruction: a comparison between MRI and ultrasound

    , MEDICAL PHYSICS, Vol: 30, Pages: 3251-3261, ISSN: 0094-2405
  • Conference paper
    Ariff B, Zambanini A, Vamadeva S, O'Neill A, Stanton A, Xu Y, Hughes A, Thom Set al., 2003,

    Differing effects of candesartan cilexetil and atenolol on carotid artery remodelling and carotid flow in hypertension

    , 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 452-452, ISSN: 0009-7322
  • Journal article
    Glor F, Ariff B, Xu XY, Augst AD, Hughes AD, McG Thom SA, Byrd S, Barratt DC, Verdonck Pet al., 2003,

    Hemodynamic impact of head rotation on carotids

    , Archives of Physiology and Biochemistry, Vol: 111, ISSN: 1381-3455
  • Journal article
    Zhao SZ, Papathanasopoulou P, Long Q, Marshall I, Xu XYet al., 2003,

    Comparative study of magnetic resonance imaging and image-based computational fluid dynamics for quantification of pulsatile flow in a carotid bifurcation phantom

    , ANNALS OF BIOMEDICAL ENGINEERING, Vol: 31, Pages: 962-971, ISSN: 0090-6964
  • Conference paper
    Ariff B, O'Neill A, Stanton A, Zambanini A, Vamadeva S, Poulter N, Sever P, Xu Y, Hughes A, Thom Set al., 2003,

    Candesartan cilexetil & atenolol have different effects on common carotid artery remodelling in hypertension

    , 13th European Meeting on Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S153-S154, ISSN: 0263-6352
  • Journal article
    Long Q, Ariff B, Zhao SZ, Thom SA, Hughes AD, Xu XYet al., 2003,

    Reproducibility study of 3D geometrical reconstruction of the human carotid bifurcation from magnetic resonance images

    , MAGNETIC RESONANCE IN MEDICINE, Vol: 49, Pages: 665-674, ISSN: 0740-3194
  • Journal article
    Augst AD, Barratt DC, Hughes AD, Glor FP, Thom SAM, Xu XYet al., 2003,

    Accuracy and reproducibility of CFD predicted wall shear stress using 3D ultrasound images

    , JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 125, Pages: 218-222, ISSN: 0148-0731
  • Conference paper
    Long Q, Merrifield R, Xu X, Firmin D, Kilner P, Yang Get al., 2003,

    Intra-ventricular blood flow simulation with patient specific geometry

    , 4th International IEEE EMBS Special Topic Conference on Information Technology Applications in Biomedicine

    This study demonstrates a subject specific approach for simulating blood flow within a left ventricle (LV) by a combined analysis of computational fluid dynamics (CFD) and magnetic resonance imaging (MRI). Time dependent LV morphology and wall movements are measured by 3D multi-slice MRI. The information is then used to build numerical meshes for CFD simulation which provides detailed 3D LV velocity and pressure distributions in the LV cavity. Issues related to mesh generation and the prescription of valvular boundary conditions are also discussed. The predicted flow patterns are compared to that of the published MR measurements, demonstrating the effectiveness of the proposed approach.

  • Conference paper
    Papathanasopoulou P, Zhao SZ, Kohler U, Robertson MB, Long Q, Hoskins P, Xu XY, Marshall Iet al., 2003,

    MRI measurement of time-resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictions

    , 10th Annual Meeting of the International-Society-for-Magnetic-Resonance-in-Medicine, Publisher: JOHN WILEY & SONS INC, Pages: 153-162, ISSN: 1053-1807
  • Journal article
    Glor FP, Long Q, Hughes AD, Augst AD, Ariff B, Thom SAM, Verdonck PR, Xu XYet al., 2003,

    Reproducibility study of magnetic resonance image-based computational fluid dynamics prediction of carotid bifurcation flow

    , ANNALS OF BIOMEDICAL ENGINEERING, Vol: 31, Pages: 142-151, ISSN: 0090-6964
  • Conference paper
    Ricard F, Brechtelsbauer C, Lawrence C, Xu Y, Pannier Aet al., 2003,

    Application of electrical resistance tomography technology to pharmaceutical processes

    , Pages: 701-706

    © 2003 International Society for Industrial Process Tomography. All rights reserved. Recent developments in the use of non-intrusive, electrical measurements to interrogate mixing processes in batch vessels have triggered a joint GSK/Imperial College project aimed at assessing the applicability of Electrical Resistance Tomography (ERT) to pharmaceutical process development. A jacketed 3.5 L glass reactor was fitted with 64 platinum sensors arranged on 4 planes and linked to an ITS P2000 data acquisition system. Several vessel/stirrer configurations aimed at mimicking typical plant reactor geometries were investigated in connection with typical process scenarios in the pharmaceutical industry. Variations in local and bulk conductivity measurements were monitored, and the data obtained were compared with spectroscopic on-line monitoring information as well as kinetic and computational fluid dynamics modelling results. Very encouraging results were achieved for model and industrial processes. This approach shows promise for on-line control of process mixing performance as well as efficiency evaluation and optimisation of reactor geometries. This allows us to conclude that ERT is a valuable tool for the development of robust manufacturing processes for Active Pharmaceutical Ingredients.

  • Conference paper
    Glor FP, Ariff B, Augst AD, Barratt DC, Hughes AD, Thom SAM, Verdonck P, Xu XYet al., 2003,

    3D ultrasound-based CFD for carotid flow prediction: a reproducibility study

    , 2nd MIT Conference on Computational Fluid and Solid Mechanics, Publisher: ELSEVIER SCIENCE BV, Pages: 1701-1704
  • Journal article
    Augst AD, Barratt DC, Hughes AD, Thom SAM, Xu XYet al., 2003,

    Various issues relating to computational fluid dynamics simulations of carotid bifurcation flow based on models reconstructed from three-dimensional ultrasound images

    , PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, Vol: 217, Pages: 393-403, ISSN: 0954-4119
  • Journal article
    Lee KW, Xu XY, 2002,

    Modelling of flow and wall behaviour in a mildly stenosed tube

    , MEDICAL ENGINEERING & PHYSICS, Vol: 24, Pages: 575-586, ISSN: 1350-4533
  • Journal article
    Zhao SZ, Ariff B, Long Q, Hughes AD, Thom SA, Stanton AV, Xu XYet al., 2002,

    Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans

    , JOURNAL OF BIOMECHANICS, Vol: 35, Pages: 1367-1377, ISSN: 0021-9290
  • Conference paper
    Glor FP, Long Q, Hughes AD, Augst AD, Ariff B, Thom SAM, Verdonck P, Xu XYet al., 2002,

    MR based CFD cardiovascular modelling: a reproducibility study on carotid blood flow

    , 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 582-582, ISSN: 0194-911X

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