@article{Armour:2021:10.1007/s10237-020-01395-4,
author = {Armour, C and Guo, B and Pirola, S and Saitta, S and Liu, Y and Dong, Z and Xu, X},
doi = {10.1007/s10237-020-01395-4},
journal = {Biomechanics and Modeling in Mechanobiology},
pages = {481--490},
title = {The influence of inlet velocity profile on predicted flow in type B aortic dissection},
url = {http://dx.doi.org/10.1007/s10237-020-01395-4},
volume = {20},
year = {2021}
}

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TY  - JOUR
AB  - In order for computational fluid dynamics to provide quantitative parameters to aid in the clinical assessment of type B aortic dissection, the results must accurately mimic the hemodynamic environment within the aorta. The choice of inlet velocity profile (IVP) therefore is crucial; however, idealised profiles are often adopted, and the effect of IVP on hemodynamics in a dissected aorta is unclear. This study examined two scenarios with respect to the influence of IVP—using (a) patient-specific data in the form of a three-directional (3D), through-plane (TP) or flat IVP; and (b) non-patient-specific flow waveform. The results obtained from nine simulations using patient-specific data showed that all forms of IVP were able to reproduce global flow patterns as observed with 4D flow magnetic resonance imaging. Differences in maximum velocity and time-averaged wall shear stress near the primary entry tear were up to 3% and 6%, respectively, while pressure differences across the true and false lumen differed by up to 6%. More notable variations were found in regions of low wall shear stress when the primary entry tear was close to the left subclavian artery. The results obtained with non-patient-specific waveforms were markedly different. Throughout the aorta, a 25% reduction in stroke volume resulted in up to 28% and 35% reduction in velocity and wall shear stress, respectively, while the shape of flow waveform had a profound influence on the predicted pressure. The results of this study suggest that 3D, TP and flat IVPs all yield reasonably similar velocity and time-averaged wall shear stress results, but TP IVPs should be used where possible for better prediction of pressure. In the absence of patient-specific velocity data, effort should be made to acquire patient’s stroke volume and adjust the applied IVP accordingly.
AU  - Armour,C
AU  - Guo,B
AU  - Pirola,S
AU  - Saitta,S
AU  - Liu,Y
AU  - Dong,Z
AU  - Xu,X
DO  - 10.1007/s10237-020-01395-4
EP  - 490
PY  - 2021///
SN  - 1617-7940
SP  - 481
TI  - The influence of inlet velocity profile on predicted flow in type B aortic dissection
T2  - Biomechanics and Modeling in Mechanobiology
UR  - http://dx.doi.org/10.1007/s10237-020-01395-4
UR  - http://hdl.handle.net/10044/1/84689
VL  - 20
ER  - 

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