@article{Torii:2010,
author = {Torii, R and Keegan, J and Wood, NB and Dowsey, AW and Hughes, AD and Yang, G-Z and Firmin, DN and Thom, SA and Xu, Y},
journal = {Annals of Biomedical Engineering},
title = {MR image-based geometric and hemodynamic investigation of the right coronary artery withdynamic vessel motion},
volume = {in press},
year = {2010}
}

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TY  - JOUR
AB  - The aim of this study was to develop a fully subject-specific model of the right coronaryartery (RCA), including dynamic vessel motion, for computational analysis to assess the effects ofcardiac-induced motion on hemodynamics and resulting wall shear stress (WSS). Vascular geometrieswere acquired in the right coronary artery (RCA) of a healthy volunteer using a navigator-gatedinterleaved spiral sequence at 14 time points during the cardiac cycle. A high temporal resolutionvelocity waveform was also acquired in the proximal region. Cardiac-induced dynamic vessel motionwas calculated by interpolating the geometries with an active contour model and a CFD simulationwith fully subject-specific information was carried out using this model. The results showed theexpected variation of vessel radius and curvature throughout the cardiac cycle, and also revealed thatdynamic motion of the right coronary artery consequent to cardiac motion had significant effects oninstantaneous WSS and oscillatory shear index (OSI). Subject specific MRI-based CFD is feasible and, ifscan duration could be shortened, this method may have potential as a non-invasive tool to investigatethe physiological and pathological role of hemodynamics in human coronary arteries.
AU  - Torii,R
AU  - Keegan,J
AU  - Wood,NB
AU  - Dowsey,AW
AU  - Hughes,AD
AU  - Yang,G-Z
AU  - Firmin,DN
AU  - Thom,SA
AU  - Xu,Y
PY  - 2010///
TI  - MR image-based geometric and hemodynamic investigation of the right coronary artery withdynamic vessel motion
T2  - Annals of Biomedical Engineering
VL  - in press
ER  - 

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