@article{Soloperto:2010,
author = {Soloperto, G and Keenan, NG and Sheppard, MN and Ohayon, J and Wood, NB and Pennell, DJ and Mohiaddin, RH and XY, X},
journal = {Artery Research},
pages = {59--65},
title = {Combined imaging, computational and histological analysis of a ruptured carotid plaque: A patient-specific analysis.},
volume = {4},
year = {2010}
}

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TY  - JOUR
AB  - Background: Rupture of carotid plaques is an important cause of cerebrovascularevents. Several factors, including wall shear stress (WSS), plaque morphology and peak capstress, have been associated with plaque vulnerability. The aim of this study was to investigatethe relationship between these factors in an in vivo human ruptured carotid plaque.Methods: A 74-year-old male presenting with a transient ischemic attack underwent carotidmagnetic resonance imaging (MRI), which indicated a ruptured plaque, followed by carotidendarterectomy, from which plaque histology was assessed. The carotid bifurcation was reconstructedfrom the MRI data, and three-dimensional flow simulations were performed usingcomputational fluid dynamics to determine WSS and related parameters. Plaque vulnerabilitywas assessed using a biomechanical method based on modified Glagov criteria.Results: The plaque rupture was just distal to the site of maximum stenosis in a region of lowWSS, where MRI and histology both demonstrated fibrous cap thinning, a large lipid pool andcalcification in the shoulder region. Plaque vulnerability analysis indicated critically vulnerableplaque at the rupture site by a wide margin.Conclusions: Both low and high WSS have been associated with plaque vulnerability, and highmechanical stress in the cap has been linked to plaque rupture, but these parameters are notroutinely assessed clinically. This study demonstrates a complete analysis by combiningimaging, histology and bio-fluid and biomechanical modelling.
AU  - Soloperto,G
AU  - Keenan,NG
AU  - Sheppard,MN
AU  - Ohayon,J
AU  - Wood,NB
AU  - Pennell,DJ
AU  - Mohiaddin,RH
AU  - XY,X
EP  - 65
PY  - 2010///
SP  - 59
TI  - Combined imaging, computational and histological analysis of a ruptured carotid plaque: A patient-specific analysis.
T2  - Artery Research
VL  - 4
ER  - 

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