BibTex format

author = {Moraldo, M and Bergamini, C and Malaweera, ASN and Dhutia, NM and Pabari, PA and Willson, K and Baruah, R and Manisty, C and Davies, JE and Xu, XY and Hughes, AD and Francis, DP},
doi = {10.1016/j.ijcard.2011.11.104},
journal = {International Journal of Cardiology},
pages = {688--695},
title = {A novel fully automated method for mitral regurgitant orifice area quantification},
url = {},
volume = {166},
year = {2013}

RIS format (EndNote, RefMan)

AB - Background: Effective regurgitant orifice area (EROA) in mitral regurgitation (MR) is difficult to quantify.Clinically it is measured using the proximal isovelocity surface area (PISA) method, which is intrinsicallynot automatable, because it requires the operator to manually identify the mitral valve orifice. We introducea new fully automated algorithm, (“AQURO”), which calculates EROA directly from echocardiographic colourM-mode data, without requiring operator input.Methods: Multiple PISA measurements were compared to multiple AQURO measurements in twenty patientswith MR. For PISA analysis, three mutually blinded observers measured EROA from the four stored videoloops. For AQURO analysis, the software automatically processed the colour M-mode datasets and analysedthe velocity field in the flow-convergence zone to extract EROA directly without any requirement for manualradius measurement.Results: Reproducibility, measured by intraclass correlation (ICC), for PISA was 0.80, 0.83 and 0.83 (for 3 observersrespectively). Reproducibility for AQURO was 0.97. Agreement between replicate measurements calculatedusing Bland-Altman standard deviation of difference (SDD) was 21,17 and 17mm2for the threerespective observers viewing independent video loops using PISA. Agreement between replicate measurementsfor AQURO was 6, 5 and 7mm2for automated analysis of the three pairs of datasets.Conclusions: By eliminating the need to identify the orifice location, AQURO avoids an important source ofmeasurement variability. Compared with PISA, it also reduces the analysis time allowing analysis and averagingof data from significantly more beats, improving the consistency of EROA quantification.AQURO, being fully automated, is a simple, effective enhancement for EROA quantification using standardechocardiographic equipment.
AU - Moraldo,M
AU - Bergamini,C
AU - Malaweera,ASN
AU - Dhutia,NM
AU - Pabari,PA
AU - Willson,K
AU - Baruah,R
AU - Manisty,C
AU - Davies,JE
AU - Xu,XY
AU - Hughes,AD
AU - Francis,DP
DO - 10.1016/j.ijcard.2011.11.104
EP - 695
PY - 2013///
SN - 1874-1754
SP - 688
TI - A novel fully automated method for mitral regurgitant orifice area quantification
T2 - International Journal of Cardiology
UR -
UR -
VL - 166
ER -