@article{Zhan:2017:10.1371/journal.pone.0172276,
author = {Zhan, W and Gedroyc, W and Xu, XY},
doi = {10.1371/journal.pone.0172276},
journal = {PLOS ONE},
title = {The effect of tumour size on drug transport and uptake in 3-D tumour models reconstructed from magnetic resonance images},
url = {http://dx.doi.org/10.1371/journal.pone.0172276},
volume = {12},
year = {2017}
}

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TY  - JOUR
AB  - Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes. The therapeutic efficacy for each tumour is evaluated by using a pharmacodynamics model based on the predicted intracellular drug concentration. Simulation results demonstrate that interstitial fluid pressure and interstitial fluid loss vary non-linearly with tumour size. Transvascular drug exchange, driven by the concentration gradient of unbound drug between blood and interstitial fluid, is more efficient in small tumours, owing to the low spatial-mean interstitial fluid pressure and dense microvasculature. However, this has a detrimental effect on therapeutic efficacy over longer periods as a result of enhanced reverse diffusion of drug to the blood circulation after the cessation of drug infusion, causing more rapid loss of drug in small tumours.
AU  - Zhan,W
AU  - Gedroyc,W
AU  - Xu,XY
DO  - 10.1371/journal.pone.0172276
PY  - 2017///
SN  - 1932-6203
TI  - The effect of tumour size on drug transport and uptake in 3-D tumour models reconstructed from magnetic resonance images
T2  - PLOS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0172276
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394424700026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/45701
VL  - 12
ER  - 

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