@article{Villette:2017:10.1007/s10237-017-0939-x,
author = {Villette, CC and Phillips, ATM},
doi = {10.1007/s10237-017-0939-x},
journal = {Biomechanics and Modeling in Mechanobiology},
pages = {2077--2091},
title = {Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations.},
url = {http://dx.doi.org/10.1007/s10237-017-0939-x},
volume = {16},
year = {2017}
}

Download

TY  - JOUR
AB  - Bone functional tissue adaptation is a multiaspect physiological process driven by interrelated mechanical and biological stimuli which requires the combined activity of osteoclasts and osteoblasts. In previous work, the authors developed a phenomenological mesoscale structural modelling approach capable of predicting internal structure of the femur based on daily activity loading, which relied on the iterative update of the cross-sectional areas of truss and shell elements representative of trabecular and cortical bones, respectively. The objective of this study was to introduce trabecular reorientation in the phenomenological model at limited computational cost. To this aim, a metamodel derived from poroelastic microscale continuum simulations was used to predict the functional adaptation of a simplified proximal structural femur model. Clear smooth trabecular tracts are predicted to form in the regions corresponding to the main trabecular groups identified in literature, at minimal computational cost.
AU  - Villette,CC
AU  - Phillips,ATM
DO  - 10.1007/s10237-017-0939-x
EP  - 2091
PY  - 2017///
SN  - 1617-7940
SP  - 2077
TI  - Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations.
T2  - Biomechanics and Modeling in Mechanobiology
UR  - http://dx.doi.org/10.1007/s10237-017-0939-x
UR  - http://hdl.handle.net/10044/1/51248
VL  - 16
ER  - 

Download