@article{Davies:2021:10.1039/D1OB01003D,
author = {Davies, J and Braddock, D and Lickiss, P},
doi = {10.1039/D1OB01003D},
journal = {Organic and Biomolecular Chemistry},
pages = {6746--6760},
title = {Silicon compounds as stoichiometric coupling reagents for direct amidation},
url = {http://dx.doi.org/10.1039/D1OB01003D},
volume = {19},
year = {2021}
}

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TY  - JOUR
AB  - Despite being one of the most frequently carried out chemical reactions in industry, there is currently no amidation protocol that is regarded as safe, high yielding, environmentally friendly and inexpensive. The direct amidation of a carboxylic acid with an amine is viewed as an inherently good solution for developing such a protocol. Since the 1960s, there has been a gradual development in the use of silicon reagents for direct amidation. This review covers the methods published to April 2021 for silicon reagent mediated direct amidation of a carboxylic acid with an amine. This review also covers the use of polymeric SiO2 to promote direct amidation.
AU  - Davies,J
AU  - Braddock,D
AU  - Lickiss,P
DO  - 10.1039/D1OB01003D
EP  - 6760
PY  - 2021///
SN  - 1477-0520
SP  - 6746
TI  - Silicon compounds as stoichiometric coupling reagents for direct amidation
T2  - Organic and Biomolecular Chemistry
UR  - http://dx.doi.org/10.1039/D1OB01003D
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/OB/D1OB01003D
UR  - http://hdl.handle.net/10044/1/90696
VL  - 19
ER  - 

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