@article{Brancaccio:2017:10.1016/j.neuron.2017.02.030,
author = {Brancaccio, M and Patton, AP and Chesham, JE and Maywood, ES and Hastings, MH},
doi = {10.1016/j.neuron.2017.02.030},
journal = {Neuron},
pages = {1420--1435.e5},
title = {Astrocytes control circadian timekeeping in the suprachiasmatic nucleus via glutamatergic signaling},
url = {http://dx.doi.org/10.1016/j.neuron.2017.02.030},
volume = {93},
year = {2017}
}

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TY  - JOUR
AB  - The suprachiasmatic nucleus (SCN) of the hypothalamus orchestrates daily rhythms of physiology and behavior in mammals. Its circadian (∼24 hr) oscillations of gene expression and electrical activity are generated intrinsically and can persist indefinitely in temporal isolation. This robust and resilient timekeeping is generally regarded as a product of the intrinsic connectivity of its neurons. Here we show that neurons constitute only one “half” of the SCN clock, the one metabolically active during circadian daytime. In contrast, SCN astrocytes are active during circadian nighttime, when they suppress the activity of SCN neurons by regulating extracellular glutamate levels. This glutamatergic gliotransmission is sensed by neurons of the dorsal SCN via specific pre-synaptic NMDA receptor assemblies containing NR2C subunits. Remarkably, somatic genetic re-programming of intracellular clocks in SCN astrocytes was capable of remodeling circadian behavioral rhythms in adult mice. Thus, SCN circuit-level timekeeping arises from interdependent and mutually supportive astrocytic-neuronal signaling.
AU  - Brancaccio,M
AU  - Patton,AP
AU  - Chesham,JE
AU  - Maywood,ES
AU  - Hastings,MH
DO  - 10.1016/j.neuron.2017.02.030
EP  - 1435
PY  - 2017///
SN  - 0896-6273
SP  - 1420
TI  - Astrocytes control circadian timekeeping in the suprachiasmatic nucleus via glutamatergic signaling
T2  - Neuron
UR  - http://dx.doi.org/10.1016/j.neuron.2017.02.030
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396990100017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0896627317301381?via%3Dihub
UR  - http://hdl.handle.net/10044/1/73333
VL  - 93
ER  - 

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