@article{Brancaccio:2019:10.1126/science.aat4104,
author = {Brancaccio, M and Edwards, MD and Patton, AP and Smyllie, NJ and Chesham, JE and Maywood, ES and Hastings, MH},
doi = {10.1126/science.aat4104},
journal = {Science},
pages = {187--192},
title = {Cell-autonomous clock of astrocytes drives circadian behavior in mammals},
url = {http://dx.doi.org/10.1126/science.aat4104},
volume = {363},
year = {2019}
}

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TY  - JOUR
AB  - Circadian (~24-hour) rhythms depend on intracellular transcription-translation negative feedback loops (TTFLs). How these self-sustained cellular clocks achieve multicellular integration and thereby direct daily rhythms of behavior in animals is largely obscure. The suprachiasmatic nucleus (SCN) is the fulcrum of this pathway from gene to cell to circuit to behavior in mammals. We describe cell type–specific, functionally distinct TTFLs in neurons and astrocytes of the SCN and show that, in the absence of other cellular clocks, the cell-autonomous astrocytic TTFL alone can drive molecular oscillations in the SCN and circadian behavior in mice. Astrocytic clocks achieve this by reinstating clock gene expression and circadian function of SCN neurons via glutamatergic signals. Our results demonstrate that astrocytes can autonomously initiate and sustain complex mammalian behavior.
AU  - Brancaccio,M
AU  - Edwards,MD
AU  - Patton,AP
AU  - Smyllie,NJ
AU  - Chesham,JE
AU  - Maywood,ES
AU  - Hastings,MH
DO  - 10.1126/science.aat4104
EP  - 192
PY  - 2019///
SN  - 0036-8075
SP  - 187
TI  - Cell-autonomous clock of astrocytes drives circadian behavior in mammals
T2  - Science
UR  - http://dx.doi.org/10.1126/science.aat4104
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000455320600053&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://science.sciencemag.org/content/363/6423/187
UR  - http://hdl.handle.net/10044/1/79169
VL  - 363
ER  - 

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