@article{Hastings:2019:10.3390/biology8010013,
author = {Hastings, MH and Maywood, ES and Brancaccio, M},
doi = {10.3390/biology8010013},
journal = {Biology},
title = {The mammalian circadian timing system and the suprachiasmatic nucleus as its pacemaker},
url = {http://dx.doi.org/10.3390/biology8010013},
volume = {8},
year = {2019}
}

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TY  - JOUR
AB  - The past twenty years have witnessed the most remarkable breakthroughs in our understanding of the molecular and cellular mechanisms that underpin circadian (approximately one day) time-keeping. Across model organisms in diverse taxa: cyanobacteria (Synechococcus), fungi (Neurospora), higher plants (Arabidopsis), insects (Drosophila) and mammals (mouse and humans), a common mechanistic motif of delayed negative feedback has emerged as the Deus exmachina for the cellular definition of ca. 24 h cycles. This review will consider, briefly, comparative circadian clock biology and will then focus on the mammalian circadian system, considering its molecular genetic basis, the properties of the suprachiasmatic nucleus (SCN) as the principal circadian clock in mammals and its role in synchronising a distributed peripheral circadian clock network. Finally, it will consider new directions in analysing the cell-autonomous and circuit-level SCN clockwork and will highlight the surprising discovery of a central role for SCN astrocytes as well as SCN neurons in controlling circadian behaviour.
AU  - Hastings,MH
AU  - Maywood,ES
AU  - Brancaccio,M
DO  - 10.3390/biology8010013
PY  - 2019///
SN  - 2079-7737
TI  - The mammalian circadian timing system and the suprachiasmatic nucleus as its pacemaker
T2  - Biology
UR  - http://dx.doi.org/10.3390/biology8010013
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30862123
UR  - http://hdl.handle.net/10044/1/69054
VL  - 8
ER  - 

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