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Journal articleGründling A, 2014,
Milestones in nucleotide signaling research: Nucleotide signals are found in bacteria as well as eukaryotes, and may act intra- or extracellularly
, Microbe, Vol: 9, Pages: 315-320, ISSN: 1558-7452 -
Journal articleBaek KT, Grundling A, Mogensen RG, et al., 2014,
β-Lactam Resistance in Methicillin-Resistant <i>Staphylococcus aureus</i> USA300 Is Increased by Inactivation of the ClpXP Protease
, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Vol: 58, Pages: 4593-4603, ISSN: 0066-4804- Author Web Link
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- Citations: 59
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Journal articleXie H-X, Lu J-F, Rolhion N, et al., 2014,
<i>Edwardsiella tarda</i>-Induced Cytotoxicity Depends on Its Type III Secretion System and Flagellin
, INFECTION AND IMMUNITY, Vol: 82, Pages: 3436-3445, ISSN: 0019-9567- Author Web Link
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- Citations: 29
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Journal articleStramer BM, Dionne MS, 2014,
Unraveling tissue repair immune responses in flies
, SEMINARS IN IMMUNOLOGY, Vol: 26, Pages: 310-314, ISSN: 1044-5323- Author Web Link
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- Citations: 9
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Journal articleStevens MP, Frankel GM, 2014,
The Locus of Enterocyte Effacement and Associated Virulence Factors of Enterohemorrhagic Escherichia coli.
, Microbiol Spectr, Vol: 2A subset of Shiga toxin-producing Escherichia coli strains, termed enterohemorrhagic E. coli (EHEC), is defined in part by the ability to produce attaching and effacing (A/E) lesions on intestinal epithelia. Such lesions are characterized by intimate bacterial attachment to the apical surface of enterocytes, cytoskeletal rearrangements beneath adherent bacteria, and destruction of proximal microvilli. A/E lesion formation requires the locus of enterocyte effacement (LEE), which encodes a Type III secretion system that injects bacterial proteins into host cells. The translocated proteins, termed effectors, subvert a plethora of cellular pathways to the benefit of the pathogen, for example, by recruiting cytoskeletal proteins, disrupting epithelial barrier integrity, and interfering with the induction of inflammation, phagocytosis, and apoptosis. The LEE and selected effectors play pivotal roles in intestinal persistence and virulence of EHEC, and it is becoming clear that effectors may act in redundant, synergistic, and antagonistic ways during infection. Vaccines that target the function of the Type III secretion system limit colonization of reservoir hosts by EHEC and may thus aid control of zoonotic infections. Here we review the features and functions of the LEE-encoded Type III secretion system and associated effectors of E. coli O157:H7 and other Shiga toxin-producing E. coli strains.
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Journal articleSong-Zhao GX, Srinivasan N, Pott J, et al., 2014,
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen
, MUCOSAL IMMUNOLOGY, Vol: 7, Pages: 763-774, ISSN: 1933-0219- Author Web Link
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- Citations: 98
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Journal articleDomingues L, Holden DW, Mota LJ, 2014,
The <i>Salmonella</i> Effector SteA Contributes to the Control of Membrane Dynamics of <i>Salmonella</i>-Containing Vacuoles
, INFECTION AND IMMUNITY, Vol: 82, Pages: 2923-2934, ISSN: 0019-9567- Author Web Link
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- Citations: 30
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Journal articleLin J, Oh S-H, Jones R, et al., 2014,
The peptide-binding cavity Is essential for Als3-mediated adhesion of Candida albicans to human cells
, Journal of Biological Chemistry, Vol: 289, Pages: 18401-18412, ISSN: 1083-351XBackground: Of the eight cell surface glycoproteins in the C. albicans Als family, Als3 makes the largest contribution to adhesion to human cells.Results: Mutation of the Als3 peptide-binding cavity (PBC) results in loss of Als3 adhesive function.Conclusion: The PBC is required for Als3 adhesive function.Significance: Interfering with PBC function is a viable strategy for inhibiting C. albicans adhesion.
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Journal articleMa L-S, Hachani A, Lin J-S, et al., 2014,
Agrobacterium tumefaciens Deploys a Superfamily of Type VI Secretion DNase Effectors as Weapons for Interbacterial Competition In Planta
, Cell Host & Microbe, Vol: 16, Pages: 94-104, ISSN: 1934-6069The type VI secretion system (T6SS) is a widespread molecular weapon deployed by many Proteobacteria to target effectors/toxins into both eukaryotic and prokaryotic cells. We report that Agrobacterium tumefaciens, a soil bacterium that triggers tumorigenesis in plants, produces a family of type VI DNase effectors (Tde) that are distinct from previously known polymorphic toxins and nucleases. Tde exhibits an antibacterial DNase activity that relies on a conserved HxxD motif and can be counteracted by a cognate immunity protein, Tdi. In vitro, A. tumefaciens T6SS could kill Escherichia coli but triggered a lethal counterattack by Pseudomonas aeruginosa upon injection of the Tde toxins. However, in an in planta coinfection assay, A. tumefaciens used Tde effectors to attack both siblings cells and P. aeruginosa to ultimately gain a competitive advantage. Such acquired T6SS-dependent fitness in vivo and conservation of Tde-Tdi couples in bacteria highlights a widespread antibacterial weapon beneficial for niche colonization.
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Journal articleEsmail H, Barry CE, Young DB, et al., 2014,
The ongoing challenge of latent tuberculosis
, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 369, ISSN: 0962-8436- Author Web Link
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- Citations: 196
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