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  • Journal article
    Painter KL, Krishna A, Wigneshweraraj S, Edwards AMet al., 2014,

    What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia?

    , Trends in Microbiology, Vol: In Press, ISSN: 0966-842X
  • Journal article
    Belardinelli JM, Larrouy-Maumus G, Jones V, de Carvalho LPS, McNeil MR, Jackson Met al., 2014,

    Biosynthesis and Translocation of Unsulfated Acyltrehaloses in Mycobacterium tuberculosis

    , Journal of Biological Chemistry, Vol: 289, Pages: 27952-27965, ISSN: 1083-351X
  • Journal article
    Collins JW, Chervaux C, Raymond B, Derrien M, Brazeilles R, Kosta A, Chambaud I, Crepin VF, Frankel Get al., 2014,

    Fermented Dairy Products Modulate <i>Citrobacter rodentium</i>-Induced Colonic Hyperplasia

    , JOURNAL OF INFECTIOUS DISEASES, Vol: 210, Pages: 1029-1041, ISSN: 0022-1899
  • Journal article
    Colas C, Menezes S, Gutierrez-Martinez E, Pean CB, Dionne MS, Guermonprez Pet al., 2014,

    An improved flow cytometry assay to monitor phagosome acidification

    , JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 412, Pages: 1-13, ISSN: 0022-1759
  • Journal article
    Moscoso JA, Jaeger T, Valentini M, Hui K, Jenal U, Filloux Aet al., 2014,

    The Diguanylate Cyclase SadC Is a Central Player in Gac/Rsm-Mediated Biofilm Formation in Pseudomonas aeruginosa

    , Journal of Bacteriology, Vol: 196, Pages: 4081-4088, ISSN: 1098-5530

    Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen and a threat for immunocompromised and cysticfibrosis patients. It is responsible for acute and chronic infections and can switch between these lifestyles upon taking an informeddecision involving complex regulatory networks. The RetS/LadS/Gac/Rsm network and the cyclic-di-GMP (c-di-GMP)signaling pathways are both central to this phenomenon redirecting the P. aeruginosa population toward a biofilm mode ofgrowth, which is associated with chronic infections. While these two pathways were traditionally studied independently fromeach other, we recently showed that cellular levels of c-di-GMP are increased in the hyperbiofilm retS mutant. Here, we have formallyestablished the link between the two networks by showing that the SadC diguanylate cyclase is central to the Gac/Rsmassociatedphenotypes, notably, biofilm formation. Importantly, SadC is involved in the signaling that converges onto the RsmAtranslational repressor either via RetS/LadS or via HptB/HsbR. Although the level of expression of the sadC gene does not seemto be impacted by the regulatory cascade, the production of the SadC protein is tightly repressed by RsmA. This adds to thegrowing complexity of the signaling network associated with c-di-GMP in P. aeruginosa. While this organism possesses morethan 40 c-di-GMP-related enzymes, it remains unclear how signaling specificity is maintained within the c-di-GMP network. Thefinding that SadC but no other diguanylate cyclase is related to the formation of biofilm governed by the Gac/Rsm pathway furthercontributes to understanding of this insulation mechanism.

  • Journal article
    Matsuo E, Leon E, Matthews SJ, Roy Pet al., 2014,

    Structure based modification of Bluetongue virus helicase protein VP6 to produce a viable VP6-truncated BTV

  • Journal article
    Brown DR, Barton G, Pan Z, Buck M, Wigneshwerarajet al., 2014,

    Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli

    , Microbial Cell, Vol: 1, Pages: 315-317, ISSN: 2311-2638

    Nitrogen is an essential element for all life, and this isno different for the bacterial cell. Numerous cellularmacromolecules contain nitrogen, including proteins,nucleic acids and cell wall components. In Escherichiacoli and related bacteria, the nitrogen stress (Ntr) responseallows cells to rapidly sense and adapt to nitrogenlimitation by scavenging for alternative nitrogensources through the transcriptional activation oftransport systems and catabolic and biosynthetic operonsby the global transcriptional regulator NtrC. Nitrogen-starvedbacterial cells also synthesize the(p)ppGpp effector molecules of a second global bacterialstress response - the stringent response. Recently,we showed that the transcription of relA, the genewhich encodes the major (p)ppGpp synthetase in E.coli, is activated by NtrC during nitrogen starvation.Our results revealed that in E. coli and related bacteria,NtrC functions in combinatorial stress and serves tocouple two major stress responses, the Ntr responseand stringent response.

  • Conference paper
    Mota J, Holden DW, Domingues L, 2014,

    The <i>Salmonella</i> effector SteA contributes to the control of membrane dynamics of <i>Salmonella</i>-containing vacuoles

    , FEBS EMBO 2014 Conference, Publisher: WILEY-BLACKWELL, Pages: 766-767, ISSN: 1742-464X
  • Journal article
    Berry AA, Yang Y, Pakharukova N, Garnett JA, Lee W-C, Cota E, Marchant J, Roy S, Tuittila M, Liu B, Inman KG, Ruiz-Perez F, Mandomando I, Nataro JP, Zavialov AV, Matthews Set al., 2014,

    Structural Insight into Host Recognition by Aggregative Adherence Fimbriae of Enteroaggregative <i>Escherichia coli</i>

    , PLOS PATHOGENS, Vol: 10, ISSN: 1553-7366
  • Journal article
    Collins JW, Keeney KM, Crepin VE, Rathinam VAK, Fitzgerald KA, Finlay BB, Frankel Get al., 2014,

    <i>Citrobacter rodentium</i>: infection, inflammation and the microbiota

    , NATURE REVIEWS MICROBIOLOGY, Vol: 12, Pages: 612-623, ISSN: 1740-1526

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