@article{Filloux:2011:10.3389/fmicb.2011.00155,
author = {Filloux, A},
doi = {10.3389/fmicb.2011.00155},
journal = {Frontiers in Microbiology},
title = {Protein secretion systems in Pseudomonas aeruginosa: an essay on diversity, evolution, and function},
url = {http://dx.doi.org/10.3389/fmicb.2011.00155},
volume = {2},
year = {2011}
}

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TY  - JOUR
AB  - Protein secretion systems are molecular nanomachines used by Gram-negative bacteria to thrive within their environment. They are used to release enzymes that hydrolyze complex carbon sources into usable compounds, or to release proteins that capture essential ions such as iron. They are also used to colonize and survive within eukaryotic hosts, causing acute or chronic infections, subverting the host cell response and escaping the immune system. In this article, the opportunistic human pathogen Pseudomonas aeruginosa is used as a model to review the diversity of secretion systems that bacteria have evolved to achieve these goals. This diversity may result from a progressive transformation of cell envelope complexes that initially may not have been dedicated to secretion. The striking similarities between secretion systems and type IV pili, flagella, bacteriophage tail, or efflux pumps is a nice illustration of this evolution. Differences are also needed since various secretion configurations call for diversity. For example, some proteins are released in the extracellular medium while others are directly injected into the cytosol of eukaryotic cells. Some proteins are folded before being released and transit into the periplasm. Other proteins cross the whole cell envelope at once in an unfolded state. However, the secretion system requires conserved basic elements or features. For example, there is a need for an energy source or for an outer membrane channel. The structure of this review is thus quite unconventional. Instead of listing secretion types one after each other, it presents a melting pot of concepts indicating that secretion types are in constant evolution and use basic principles. In other words, emergence of new secretion systems could be predicted the way Mendeleïev had anticipated characteristics of yet unknown elements.
AU  - Filloux,A
DO  - 10.3389/fmicb.2011.00155
PY  - 2011///
SN  - 1664-302X
TI  - Protein secretion systems in Pseudomonas aeruginosa: an essay on diversity, evolution, and function
T2  - Frontiers in Microbiology
UR  - http://dx.doi.org/10.3389/fmicb.2011.00155
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208863500165&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65710
VL  - 2
ER  - 

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