BibTex format

author = {Bosi, E and Fondi, M and Orlandini, V and Perrin, E and Maida, I and de, Pascale D and Tutino, ML and Parrilli, E and Lo, Giudice A and Filloux, A and Fani, R},
doi = {10.1186/s12864-016-3382-y},
journal = {BMC Genomics},
title = {The pangenome of (Antarctic) Pseudoalteromonas bacteria: evolutionary and functional insights},
url = {},
volume = {18},
year = {2017}

RIS format (EndNote, RefMan)

AB - Background:Pseudoalteromonas is a genus of ubiquitous marine bacteria used as model organisms to study the biological mechanisms involved in the adaptation to cold conditions. A remarkable feature shared by these bacteria is their ability to produce secondary metabolites with a strong antimicrobial and antitumor activity. Despite their biotechnological relevance, representatives of this genus are still lacking (with few exceptions) an extensive genomic characterization, including features involved in the evolution of secondary metabolites production. Indeed, biotechnological applications would greatly benefit from such analysis.Results:Here, we analyzed the genomes of 38 strains belonging to different Pseudoalteromonas species and isolated from diverse ecological niches, including extreme ones (i.e. Antarctica). These sequences were used to reconstruct the largest Pseudoalteromonas pangenome computed so far, including also the two main groups of Pseudoalteromonas strains (pigmented and not pigmented strains). The downstream analyses were conducted to describe the genomic diversity, both at genus and group levels. This allowed highlighting a remarkable genomic heterogeneity, even for closely related strains. We drafted all the main evolutionary steps that led to the current structure and gene content of Pseudoalteromonas representatives. These, most likely, included an extensive genome reduction and a strong contribution of Horizontal Gene Transfer (HGT), which affected biotechnologically relevant gene sets and occurred in a strain-specific fashion. Furthermore, this study also identified the genomic determinants related to some of the most interesting features of the Pseudoalteromonas representatives, such as the production of secondary metabolites, the adaptation to cold temperatures and the resistance to abiotic compounds.Conclusions:This study poses the bases for a comprehensive understanding of the evolutionary trajectories followed in time by this peculiar bact
AU - Bosi,E
AU - Fondi,M
AU - Orlandini,V
AU - Perrin,E
AU - Maida,I
AU - de,Pascale D
AU - Tutino,ML
AU - Parrilli,E
AU - Lo,Giudice A
AU - Filloux,A
AU - Fani,R
DO - 10.1186/s12864-016-3382-y
PY - 2017///
SN - 1471-2164
TI - The pangenome of (Antarctic) Pseudoalteromonas bacteria: evolutionary and functional insights
T2 - BMC Genomics
UR -
UR -
UR -
VL - 18
ER -