Citation

BibTex format

@article{Thayyil:2019:10.1089/ther.2018.0052,
author = {Thayyil, S and Liow, N and Montaldo, P and Lally, P and Teiserskas, J and Bassett, P and Oliveira, V and Mendoza, J and Slater, R and Shankaran, S},
doi = {10.1089/ther.2018.0052},
journal = {Therapeutic Hypothermia and Temperature Management},
title = {Pre-emptive morphine during therapeutic hypothermia after neonatal encephalopathy: a secondary analysis},
url = {http://dx.doi.org/10.1089/ther.2018.0052},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Although therapeutic hypothermia (TH) improves outcomes after neonatal encephalopathy (NE), the safety and efficacy of preemptive opioid sedation during cooling therapy is unclear. We performed a secondary analysis of the data from a large multicountry prospective observational study (Magnetic Resonance Biomarkers in Neonatal Encephalopathy [MARBLE]) to examine the association of preemptive morphine infusion during TH on brain injury and neurodevelopmental outcomes after NE. All recruited infants had 3.0 Tesla magnetic resonance imaging and spectroscopy at 1 week, and neurodevelopmental outcome assessments at 22 months. Of 223 babies recruited to the MARBLE study, the data on sedation were available from 169 babies with moderate (n = 150) or severe NE (n = 19). Although the baseline characteristics and admission status were similar, the babies who received morphine infusion (n = 141) were more hypotensive (49% vs. 25%, p = 0.02) and had a significantly longer hospital stay (12 days vs. 9 days, p = 0.009) than those who did not (n = 28). Basal ganglia/thalamic injury (score ≥1) and cortical injury (score ≥1) was seen in 34/141 (24%) and 37/141 (26%), respectively, of the morphine group and 4/28 (14%) and 3/28 (11%) of the nonmorphine group (p > 0.05). On regression modeling adjusted for potential confounders, preemptive morphine was not associated with mean (standard deviation [SD]) thalamic N-acetylaspartate (NAA) concentration (6.9 ± 0.9 vs. 6.5 ± 1.5; p = 0.97), and median (interquartile range) lactate/NAA peak area ratios (0.16 [0.12–0.21] vs. 0.13 [0.11–0.18]; p = 0.20) at 1 week, and mean (SD) Bayley-III composite motor (92 ± 23 vs. 94 ± 10; p = 0.98), language (89 ± 22 vs. 93 ± 
AU - Thayyil,S
AU - Liow,N
AU - Montaldo,P
AU - Lally,P
AU - Teiserskas,J
AU - Bassett,P
AU - Oliveira,V
AU - Mendoza,J
AU - Slater,R
AU - Shankaran,S
DO - 10.1089/ther.2018.0052
PY - 2019///
SN - 2153-7658
TI - Pre-emptive morphine during therapeutic hypothermia after neonatal encephalopathy: a secondary analysis
T2 - Therapeutic Hypothermia and Temperature Management
UR - http://dx.doi.org/10.1089/ther.2018.0052
UR - http://hdl.handle.net/10044/1/67323
ER -