BibTex format

author = {Le, Friec G and Sheppard, D and Whiteman, P and Karsten, CM and Shamoun, SA-T and Laing, A and Bugeon, L and Dallman, MJ and Melchionna, T and Chillakuri, C and Smith, RA and Drouet, C and Couzi, L and Fremeaux-Bacchi, V and Koehl, J and Waddington, SN and McDonnell, JM and Baker, A and Handford, PA and Lea, SM and Kemper, C},
doi = {10.1038/ni.2454},
journal = {Nature Immunology},
pages = {1213--1221},
title = {The CD46-Jagged1 interaction is critical for human T(H)1 immunity},
url = {},
volume = {13},
year = {2012}

RIS format (EndNote, RefMan)

AB - CD46 is a complement regulator with important roles related to the immune response. CD46 functions as a pathogen receptor and is a potent costimulator for the induction of interferon-γ (IFN-γ)-secreting effector T helper type 1 (TH1) cells and their subsequent switch into interleukin 10 (IL-10)-producing regulatory T cells. Here we identified the Notch family member Jagged1 as a physiological ligand for CD46. Furthermore, we found that CD46 regulated the expression of Notch receptors and ligands during T cell activation and that disturbance of the CD46-Notch crosstalk impeded induction of IFN-γ and switching to IL-10. Notably, CD4+ T cells from CD46-deficient patients and patients with hypomorphic mutations in the gene encoding Jagged1 (Alagille syndrome) failed to mount appropriate TH1 responses in vitro and in vivo, which suggested that CD46-Jagged1 crosstalk is responsible for the recurrent infections in subpopulations of these patients.
AU - Le,Friec G
AU - Sheppard,D
AU - Whiteman,P
AU - Karsten,CM
AU - Shamoun,SA-T
AU - Laing,A
AU - Bugeon,L
AU - Dallman,MJ
AU - Melchionna,T
AU - Chillakuri,C
AU - Smith,RA
AU - Drouet,C
AU - Couzi,L
AU - Fremeaux-Bacchi,V
AU - Koehl,J
AU - Waddington,SN
AU - McDonnell,JM
AU - Baker,A
AU - Handford,PA
AU - Lea,SM
AU - Kemper,C
DO - 10.1038/ni.2454
EP - 1221
PY - 2012///
SN - 1529-2908
SP - 1213
TI - The CD46-Jagged1 interaction is critical for human T(H)1 immunity
T2 - Nature Immunology
UR -
UR -
UR -
VL - 13
ER -