ICORG Group Photo

Contact

Western Eye Hospital
3rd Floor, A&E side
153 - 173 Marylebone Road
London NW1 5QH
+44 (0)20 3312 3206
imperial.icorg@nhs.net
Twitter: @ImperialOph

What we do

At the Imperial College Ophthalmic Research Group (ICORG) Clinical Trials Unit, we coordinate all ophthalmology research done within the Department of Surgery and Cancer and Western Eye Hospital and promote multidisciplinary research and collaborations within and outside Imperial College. We are dedicated to establishing new methods of diagnosis of early disease to avoid disability, identifying early markers of cell processes in neurodegenerative disease and investigating new treatments for low vision and blindness, including developing novel modes of drug delivery and improved treatment strategies. 

Research areas

  • Glaucoma - primary open angle glaucoma (POAG), acute angle glaucoma, ocular hypertension
  • Macular - age-related macular degeneration (AMD), diabetic macular oedema (DMO), polypoidal choroidal vasculopathy, macular telangiectasia (MacTel)
  • Oculoplastics, vitreoretinal, cataracts, genetic, paediatric

Summary of some of our current research

Investigator-led
  • DARC, Phase 2 - The DARC Technology (Detection of Apoptosing Retinal Cells) is a novel technique that utilises the unique optical properties of the eye to allow direct visualisation of retinal nerve cells dying through the process of apoptosis. 
  • POPPY- Perforated punctal plug as an alternative to the three snip punctoplasty for the treatment of acquired lacrimal punctum.
  • LT-ROP - Long-term outcomes in adults with a history of retinopathy of prematurity (ROP)
Industry led
  • Evaluating the safety and efficacy of Bimatoprost SR (sustained-release) biodegradable intravitreal implant in patients with open-angle glaucoma and ocular hypertension. (Allergan)
  • Assessing the safety, efficacy and cost-effectiveness of intravitreal therapy in patients with neovascular age-related macular degeneration, diabetic macular oedema and central retinal vein occlusion. (Multiple)

Tabs

Get involved

Patient and Public Involvement
Support
 

 

Collaborations

Imperial

  • Dr Reza Bahmanyar
  • Ms Melanie Corbett
  • Ms Laura Crawley
  • Mr Graham Duguid
  • Ms Rajni Jain
  • Professor Chris McCleod
  • Dr Richard Nicholas
  • Professor Nick Oliver
  • Dr Simona Parinella
  • Professor Guy Rutter
  • Dr Joseph M Sherwood
  • Dr Ali Yetisen

UCL

  • Dr Satyanarayana Somavarapu
  • Professor Matteo Carandini
  • Professor Stephen Moss
  • Professor Tom Salt
  • Professor Frederick Fitzke
  • Professor Adam Sillito
  • Professor Michael Duchen
  • Dr Frances Edwards
  • Professor Mike Cheetham
  • Professor Christiana Ruhrberg
  • Professor Steven Dakin
  • Professor David Selwood
  • Professor Chris Dainty
  • Professor Seb Ourselin
  • Dr Jonathan Schott

Global

  • Professor Neeraj Agarwal (NEI)
  • Professor Francesco Bandello (Milan)
  • Professor Alastair Barber (University of Pennsylvania)
  • Professor Josef Bille (Heidelberg)
  • Professor John Danias (SUNY, New York)
  • Dr Fabiana D'Esposito (Naples)
  • Professors Crawford Downs and Chris Girkin (Birmingham, Alabama)
  • Professor John Flanagan (Waterloo, Canada)
  • Professor Stefano Gandolfi (Parma, Italy)
  • Professor Tom Gardner (University of Michigan)
  • Professor Amiram Grinvald (Tel Aviv)
  • Professor Illana Gozes (Tel Aviv)
  • Dr Carlo Nucci (Rome)
  • Professor Peter Stalmans (University Leuven, Belgium)
  • Dr Gerhard Zinser (Heidelberg)

Our team

Eduardo Maria Normando

Eduardo Maria Normando

Eduardo Maria Normando
Clinical Senior Lecturer

Zena Rodrigues

Zena Rodrigues

Zena Rodrigues
Ophthalmic Nurse Consultant

Fabiana D'Esposito

Fabiana D'Esposito

Fabiana D'Esposito
Consultant Ophthalmologist, Genetics

Timothy Edward Yap

Dr Timothy Edward Yap

Timothy Edward Yap
Clinical Research Fellow


Research Areas

Selected Publications

Cordeiro, M. F. (2016) ‘Eyeing the brain’, Acta Neuropathologica. Springer Berlin Heidelberg, 132(6),pp. 765–766. doi: 10.1007/s00401-016-1628-z

Cordeiro, M. F. et al. (2017) ‘Real-time imaging of single neuronal cell apoptosis in patients with glaucoma.’, Brain : a journal of neurology, 140(6), pp. 1757–1767. doi: 10.1093/brain/awx088

Davis, B. M. et al. Topical Curcumin Nanocarriers are Neuroprotective in Eye Disease. Sci. Rep. 8, 11066 (2018). doi: 10.1038/s41598-018-29393-8 

De Groef, L. and Cordeiro, M. F. (2018) ‘Is the Eye an Extension of the Brain in Central Nervous System Disease?’, Journal of Ocular Pharmacology and Therapeutics, 34(1–2), pp. 129–133. doi: 10.1089/jop.2016.0180

Normando, E. M. et al. (2016) ‘The retina as an early biomarker of neurodegeneration in a rotenone-induced model of Parkinson’s disease: evidence for a neuroprotective effect of rosiglitazone in the eye and brain’, Acta Neuropathologica Communications, 4(1), p. 86. doi: 10.1186/s40478-016-0346-z

Yap, T., Normando, E.M. & Cordeiro, M.F. (2018) 'Redefining clinical outcomes and endpoints in glaucoma,' Expert Review in Ophthalmology, 13(2), pp. 113-127. doi:10.1080/17469899.2018.1465820 (eprint link)