Projects

General Biomedical Research

  • Metabonomic profiling of Deep Vein Thrombosis at different time points of thrombus maturation in an animal model.
  • Reversing epigenetic silencing to treat disease
  • Identification of novel factors involved in regulation of c-di-AMP production in Staphylococcus aureus
  • The role of Frizzled-4 in endothelial mechanosignalling
  • Characterisation of the interaction between TSC2 and Rheb
  • Neuropilin-1 is a new regulator of mitochondrial activity and iron homeostasis in endothelial cells
  • Lower reproductive tract microbial metabolites and their role in modulation of local inflammatory pathways
  • Elucidating the roles of Liver-X receptors in the adrenal gland 
  • Metabolic Investigation of Burn Injury
  • Gender and spine shape differences in spine movements across young adults
  • Role of the transcription factor TCF7L2 in glucose metabolism in mice
  • Understanding the function of sleep. A systems biology approach.
  • Immunosuppressive T cells in chronic liver disease
  • Making and characterising a pyruvate dehydrogenase mutant in Pseudomonas aeruginosa
  • Metabolic profiling of colonic organoids for studying colorectal cancer
  • Mechanisms of cellular action and metabolic impact of necrotoxic snake venom toxins.
  • The role of the Calcium Sensing Receptor in appetite regulation and the secretion of gut hormones
  • Central carbon metabolism UPLC-MS-based metabonomics in atherosclerotic plaques. Pathway mapping and result validation.
  • Boosting named entity recognition from biomedical text with recurrent neural network approaches 
  • Conformational dynamics of the voltage sensing in genetically encoded voltage indicators
  • Characterisation of Phosphodiesterase12 (PDE12) inhibitors
  • Investigating geno- and cytotoxicity of faecal biochemical components after weight loss surgery
  • Modulation of neural activation during shortening, isometric, and lengthening contractions in trunk muscles.
  • Could Transcranial Magnetic Stimulation be used as an intra-operative monitor of spinal cord function during vascular surgery? 
  • How does bisphosphonate therapy affect the bone's nanostructure?
  • Neurological Effects of sub-acute Carbon Monoxide Toxicity
  • Novel neuroprotective treatments for traumatic brain injury
  • Grasping chirality with both hands: development and application of a high-throughput enantiospecific assay for lactic acid.
  • Understanding the role of myo-inositol in the cellular response to nanoparticle exposure.
  • Evaluation of a trans-splicing gene therapy approach for the treatment of Von Willebrands Disease
  • Regulation of epithelial cell junctions by DDR1 
  • Role of TRF2 in stress response of human neural progenitor cells
  • Disturbed Amino Acid Metabolism in Liver Cirrhosis
  • Longitudinal data analysis of Lung Function
  • Using computational and system biology approaches to understand different clinical manifestations of Tuberculosis 
  • Modulation of GLP-1 receptor-induced incretin responses by epidermal growth factor receptor in pancreatic beta cells
  • How does milk delivery method influence breastfeeding and body composition? A systematic review and meta-analysis
  • Discovery of novel biomarkers of motor neurone disease via NMR-based metabolomics
  • Understanding the consequences of mutation of a key bacterial enzyme during infection
  • Diet and colon cancer risk in African Americans and rural Africans
  • Cellular and molecular mechanisms of neutrophil interaction and clustering in the spleen
  • Crystallization of Proteins Related to Therapy
  • Does inflammation suppress ribosomal RNA expression in skeletal muscle
  • Super resolution imaging of the neurovascular interface in adult neurogenesis
  • Functional investigation of the Trim32 E3 ubiquitin ligase during bacterial infection

Anaesthetics, Pain Medicine and Intensive Care

  • Mechanisms of cell death in ventilator-induced lung injury
  • Mechanisms of cell death in experimental ARDS
  • Mapping inflammation-induced mitogen- and stress-activated protein kinase 1/2-dependent molecular changes in primary sensory neurons
  • Molecular basis for TRPV1 autosensitisation in primary sensory neurons
  • The role of SHIP-1 in anandamide synthesis in spinal microglia 
  • Inflammation-induced post-translation modification in histones in primary sensory neurons
  • Neurochemical characterisation of spinal dorsal horn neurones which exhibit MSK1/2 activation in inflammation of peripheral tissues. 
  • Propagation of systemic inflammation by circulating microvesicles in sepsis 
  • Duration of delirium on the Burns Intensive Care Unit: prevalence of risk factors and association with mortality and length of stay
  • Weaning from mechanical ventilation: comparison of open-loop decision support system and routine care, in general medical ICU
  • Altering pain perception with non-invasive brain stimulation
  • Role of necroptosis and stem cell mediated tissue regeneration during ischemia-reperfusion injury in renal transplantation.
  • Role of necroptosis and stem cell repair in perinatal hypoxic-ischaemic brain injury
  • Investigation of the pleural space as a site of inflammation during ARDS

Bacterial Pathogenesis and Infection

  • The Type VI Secretion System: Effector Proteins for Host Cell Subversion
  • A novel mechanism of virulence regulation in Staphylococcus aureus
  • Does combination therapy reduce the emergence of antibiotic resistance?
  • Contribution of proteins of unknown function to antibiotic resistance and virulence of Listeria monocytogenes
  • New roles for caspase-8 in antibacterial immune responses.
  • Deciphering the role of transcription factors in the coordination of the stress response in uropathogenic E. coli by genome wide binding analysis
  • Host cell membrane targeting of Salmonella integral membrane effector proteins
  • Molecular analysis of a bacterial metabolic brake
  • Emerging lineages of group A streptococcus: role of the modern environment 
  • Free fatty acids and immune function in Drosophila
  • Functional investigation of the Trim32 E3 ubiquitin ligase during bacterial infection

Data Science

  • Using data science to investigate the occurrence of emerging and re-emerging global infectious disease: mapping transmission and predicting future outbreaks
  • Deep Learning predictive models of molecular phenotypes for overall survival in cancer
  • Getting the big picture on UK Biobank brain imaging data
  • Novel big-data analytical tools for detection of principal determinants of unusual variations within a registry of clinical records for neonatal care
  • Association of radiological and genomics features for cancer stratification
  • Leveraging high-performance computing to improve significance estimation in phenomic profiling.
  • Uncovering the metabolic dysregulation induced by early-life undernutrition and its impact on human development
  • A gene regulatory network approach to understanding human islets' dynamical response to glucose and identifying new therapeutic targets for Type 2 Diabetes (T2D).
  • Entropy framework for tumor-induced molecular heterogeneity assessment using mass spectrometry imaging
  • Machine learning and in silico fragmentation pattern prediction for annotation of unknown metabolites in high-throughput analytical metabonomics
  • Processing large scale chromatography-mass spectrometry data for improved information recovery
  • Information theoretic analysis of spatial memory encoding in the mouse hippocampus
  • Automatic Detection of Hand Signs
  • Movement Classification with Wearable Sensors
  • Integration of multi-platform metabolomics data using cloud computing
  • Metabolomics in the Cloud: Interactive data analysis with PhenoMeNal
  • Changes in cause of mortality over time in people with COPD
  • Beta-cell transcriptome annotation
  • Pattern recognition driving the regulation of cell-cell adhesion and motility

Microbiome in Health and Disease

  • Does the radiotherapy change the gut microbial activity of the patients with prostate cancer?
  • Metabolic investigation of Endobarrier surgery for Obesity and Type 2 Diabetes 
  • Can the vaginal and endometrial microbiota determine IVF outcomes?
  • The role of gut bacteria in the activation of T cells
  • Expanding the healthy gut phageome
  • Investigate the microbiome in a model of colon cancer
  • Development of a high-throughput metabolic profiling protocol for human faecal analysis
  • Characterisation of protease producing bacteria from the human gut
  • Determining the identity of active colonizers of the human gut which are able to degrade bile.

Molecular Basis of Human Disease

  • Inhibition of DDR1 signalling: developing signal blocking antibodies into a therapeutic 
  • Structural Study of the Arp5/Ies6 component of the INO80 Chromatin Remodelling Complex
  • Dynamics of eukaryotic histone exchange with single molecule resolution
  • Crystallisation and structural analysis of the diabetes-associated lipid transfer protein STARD10
  • Structural and biochemical dissection of myosin motors from the malaria parasite, Plasmodium falciparum
  • Structural and functional analysis of the Schistosoma mansoni cercarial elastase
  • Molecular investigation of the basal complex of the Type VI secretion system (T6SS) of Pseudomonas aeruginosa
  • Identification of non-coding de novo mutations underlying autism spectrum disorders 
  • Structural and biochemical characterisations of key proteins involved in DNA damage response
  • Structural characterisation of tumour suppressor BRCA1-PALB2
  • A blood-based multi-transcriptome signature: a novel biomarker for neuroendocrine tumours
  • Determining the role of FOXM1 and its cofactors in breast cancer metastasis and drug resistance
  • Functional non-coding RNAs in pancreatic beta cells
  • Structural Characterisation of the type VI secretion system from Pseudomonas aeruginosa
  • Dissecting functional roles of GSDMB in epithelial inflammation
  • Structural and functional characterization of Human T-cell Lymphotropic virus integrase

Respiratory and Cardiovascular Science

  • Defining the role of Macrophage Metabolic Reprogramming in Asthma
  • Transcriptional and Epigenetic Control of Endothelial Differentiation
  • Novel metabolic profiling of methylarginines and associated amines in personalised medicine
  • Role of VEGF-dependent activation of ERG transcription factor isoforms in regulating angiogenesis
  • A systemic review and meta-analysis of cardiovascular complications in chronic obstructive pulmonary disease.
  • The role of chemokines in ILC2 recruitment to the allergic lung
  • Towards an understanding of ligand bias at chemokine receptor CCR4
  • Microdomain dependent phosphodiesterase activity within human iPSC-CMs 
  • Investigating the anti-fibrotic effect of Ursodeoxycholic acid in adult human fibroblasts in vitro.
  • The structural and functional characteristics of mouse atrial cardiomyocytes
  • Changes in composition of heterocellular myocardial contacts after hypertrophy in cardiomyocytes 
  • Functional assessment of βAR activity in cardiomyocytes from patients with atrial fibrillation
  • Interrogation of transcriptomic pathways to explain the lipid mediator production and iron dysregulation in COPD
  • Interrogation of transcriptomic pathways to explain the sensitisation to pathogen stimuli in man
  • Assessing the impact of HIV therapeutics upon platelet activation and calcium signalling
  • Understanding how ibuprofen-like drugs cause heart attacks and strokes by effects on the kidney or blood vessels
  • Using totally new genetically-modified mouse strains to understand prostacyclin, one of the bodies most fundamental cardio-protective hormone pathways
  • Prediction of fibrillation by electrogram morphology analysis and supervised machine learning
  • Histological validation of scar and fibre orientation depicted in magnetic resonance imaging
  • Immunoglobulins and host-bacterial interactions in fibrotic lung disease
  • Assessing granulocyte function using flow cytometry and chemotaxis assays in children with preschool wheeze and asthma
  • Defining the role of itaconic acid in chronic lung disease
  • Does the AMPK activator Metformin regulate accelerated lung ageing in COPD?
  • Role of matrix metalloproteinases in host immunity to respiratory infections and allergens
  • The Role of Macrophage Cell Death in Orchestrating the Immune Response to Apsergillus fumigatus Infection in Cystic Fibrosis
  • Investigating an ex-vivo Forster Resonance Energy Transfer (FRET) methodology for assessing intra-cellular cAMP responses in transgenic animals

Toxicological Science

  • Validation and application of an in vitro model to probe carboxylesterase activity using hepatic and intestinal microsomes
  • Characterising the metabolic phenotypic response of lung epithelial cells to specific nanoparticle exposures
  • Quantitative structure-metabolism relationships of benzoic acids
  • Evaluating novel chemical descriptors for prediction of drug metabolism and toxicity
  • Integrating in vitro and in silico methods for predicting aromatic amide hydrolysis