@article{Yu:2022:10.3389/fbioe.2022.808113,
author = {Yu, X and Nguyen, T and Wu, T and Ghajari, M},
doi = {10.3389/fbioe.2022.808113},
journal = {Frontiers in Bioengineering and Biotechnology},
title = {Non-lethal blasts can generate cavitation in cerebrospinal fluid while severe helmeted impacts cannot: a novel mechanism for blast brain injury},
url = {http://dx.doi.org/10.3389/fbioe.2022.808113},
volume = {10},
year = {2022}
}

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TY  - JOUR
AB  - Cerebrospinal fluid (CSF) cavitation is a likely physical mechanism for producing traumatic brain injury (TBI) under mechanical loading. In this study, we investigated CSF cavitation under blasts and helmeted impacts which represented loadings in battlefield and road traffic/sports collisions. We first predicted the human head response under the blasts and impacts using computational modelling and found that the blasts can produce much lower negative pressure at the contrecoup CSF region than the impacts. Further analysis showed that the pressure waves transmitting through the skull and soft tissue are responsible for producing the negative pressure at the contrecoup region. Based on this mechanism, we hypothesised that blast, and not impact, can produce CSF cavitation. To test this hypothesis, we developed a one-dimensional simplified surrogate model of the head and exposed it to both blasts and impacts. The test results confirmed the hypothesis and computational modelling of the tests validated the proposed mechanism. These findings have important implications for prevention and diagnosis of blast TBI.
AU  - Yu,X
AU  - Nguyen,T
AU  - Wu,T
AU  - Ghajari,M
DO  - 10.3389/fbioe.2022.808113
PY  - 2022///
SN  - 2296-4185
TI  - Non-lethal blasts can generate cavitation in cerebrospinal fluid while severe helmeted impacts cannot: a novel mechanism for blast brain injury
T2  - Frontiers in Bioengineering and Biotechnology
UR  - http://dx.doi.org/10.3389/fbioe.2022.808113
UR  - http://hdl.handle.net/10044/1/97694
VL  - 10
ER  - 

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