@article{Fabrini:2022:10.1021/acs.nanolett.1c03314,
author = {Fabrini, G and Minard, A and Brady, R and Di, Antonio M and Di, Michele L},
doi = {10.1021/acs.nanolett.1c03314},
journal = {Nano Letters: a journal dedicated to nanoscience and nanotechnology},
pages = {602--611},
title = {Cation-responsive and photocleavable hydrogels from non-canonical amphiphilic DNA nanostructures},
url = {http://dx.doi.org/10.1021/acs.nanolett.1c03314},
volume = {22},
year = {2022}
}

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TY  - JOUR
AB  - Thanks to its biocompatibility, versatility and programmable interactions, DNA has been proposed as a building block for functional, stimuli-responsive frameworks with applications in biosensing, tissue engineering and drug delivery. Of particular importance for in vivo applications is the possibility of making such nano-materials responsive to physiological stimuli. Here we demonstrate how combining non-canonical DNA G-quadruplex (G4) structures with amphiphilic DNA constructs yields nanos-tructures, which we termed “Quad-Stars”, capable of assembling into responsive hydrogel particles via a straightforward, enzyme-free, one-pot reaction. The embedded G4 structures allow one to trigger and control the assembly/disassembly in a reversible fashion by adding or removing K+ ions. Furthermore, the hydrogel aggregates can be photo disassembled upon near-UV irradiation in the presence of a porphyrin photosensitiser. The combinedreversibility of assembly, responsiveness and cargo-loading capabilities of the hydrophobic moieties make Quad-Stars a promising candidate for biosensors and responsive drug delivery carriers.
AU  - Fabrini,G
AU  - Minard,A
AU  - Brady,R
AU  - Di,Antonio M
AU  - Di,Michele L
DO  - 10.1021/acs.nanolett.1c03314
EP  - 611
PY  - 2022///
SN  - 1530-6984
SP  - 602
TI  - Cation-responsive and photocleavable hydrogels from non-canonical amphiphilic DNA nanostructures
T2  - Nano Letters: a journal dedicated to nanoscience and nanotechnology
UR  - http://dx.doi.org/10.1021/acs.nanolett.1c03314
UR  - https://pubs.acs.org/doi/10.1021/acs.nanolett.1c03314
UR  - http://hdl.handle.net/10044/1/93189
VL  - 22
ER  - 

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