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  • Journal article
    Almoudaris AM, Mamidanna R, Bottle A, Aylin P, Vincent C, Faiz O, Hanna GBet al., 2013,

    Failure to Rescue Patients After Reintervention in Gastroesophageal Cancer Surgery in England

    , JAMA SURGERY, Vol: 148, Pages: 272-276, ISSN: 2168-6254
  • Journal article
    Bottle A, Aylin P, Bell D, 2013,

    Predictors of readmission in heart failure patients vary by cause of readmission Hospital-level cause-specific readmission rates show no correlation

    , 2013 IEEE INTERNATIONAL CONFERENCE ON HEALTHCARE INFORMATICS (ICHI 2013), Pages: 563-566
  • Journal article
    Burns EM, Currie A, Bottle A, Aylin P, Darzi A, Faiz Oet al., 2013,

    Minimal-access colorectal surgery is associated with fewer adhesion-related admissions than open surgery

    , Br J Surg, Vol: 100, Pages: 152-159, ISSN: 1365-2168

    BACKGROUND: This study aimed to describe national intermediate-term admission rates for incisional hernia or clinically apparent adhesions following colorectal surgery, and to compare rates following laparoscopic and open approaches. METHODS: Patients undergoing primary colorectal resection between 2002 and 2008 were included from the Hospital Episode Statistics database. Subsequent inpatient admissions were extracted for up to 3 years after the initial operation or to the end of the study period. Outcomes examined were admissions with a diagnosis of, or operative interventions for, incisional hernia or adhesions. RESULTS: A total of 187 148 patients were included between 2002 and 2008, with median follow-up of 31.8 (interquartile range 13.1-35.3) months. Some 8885 (4.7 per cent) of these patients were admitted with a diagnosis of, or underwent a repair of, an incisional hernia. In multiple regression analysis, use of laparoscopy was not a predictor of operative intervention for incisional hernia (odds ratio 1.09, 95 per cent confidence interval (c.i.) 0.99 to 1.21; P = 0.083). Some 15 125 (8.1 per cent) of the patients were admitted with a diagnosis of adhesions or had a procedure for division of adhesions. Overall, 3.5 per cent (6637 of 187 148) of patients underwent adhesiolysis. Patients selected for a laparoscopic procedure had lower rates of admission for adhesions (6.3 per cent (692 of 11 013) for laparoscopic versus 8.2 per cent (14 433 of 176 135) for open surgery; P < 0.001) and reintervention for adhesions (2.8 per cent (305 of 11 013) versus 3.6 per cent (6325 of 176 135) respectively; P < 0.001) than those undergoing an open procedure. In multiple regression analysis, patients selected for a laparoscopic procedure had lower subsequent intervention rates for adhesions (odds ratio 0.80, 95 per cent c.i. 0.71 to 0.90; P < 0.001). DISCUSSION: Patients undergoing colorectal resection who are selected for the laparoscopic approach have a lower risk o

  • Journal article
    Koshy E, Murray J, Bottle A, Aylin P, Sharland M, Majeed A, Saxena Set al., 2012,

    Significantly increasing hospital admissions for acute throat infections among children in England: is this related to tonsillectomy rates?

    , ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 97, Pages: 1064-1068, ISSN: 0003-9888
  • Journal article
    Sharabiani MTA, Aylin P, Bottle A, 2012,

    Systematic Review of Comorbidity Indices for Administrative Data

    , MEDICAL CARE, Vol: 50, Pages: 1109-1118, ISSN: 0025-7079
  • Journal article
    King C, Alvarez LG, Holmes A, Moore L, Galletly T, Aylin Pet al., 2012,

    Risk factors for healthcare-associated urinary tract infection and their applications in surveillance using hospital administrative data: a systematic review

    , JOURNAL OF HOSPITAL INFECTION, Vol: 82, Pages: 219-226, ISSN: 0195-6701
  • Journal article
    Palmer WL, Bottle A, Davie C, Vincent CA, Aylin Pet al., 2012,

    Dying for the Weekend A Retrospective Cohort Study on the Association Between Day of Hospital Presentation and the Quality and Safety of Stroke Care

    , ARCHIVES OF NEUROLOGY, Vol: 69, Pages: 1296-1302, ISSN: 0003-9942
  • Journal article
    Mamidanna R, Eid-Arimoku L, Almoudaris AM, Burns EM, Bottle A, Aylin P, Hanna GB, Faiz Oet al., 2012,

    Poor 1-Year Survival in Elderly Patients Undergoing Nonelective Colorectal Resection

    , DISEASES OF THE COLON & RECTUM, Vol: 55, Pages: 788-796, ISSN: 0012-3706
  • Journal article
    Sanders RD, Bottle A, Jameson SS, Mozid A, Aylin P, Edger L, Ma D, Reed MR, Walters M, Lees KR, Maze Met al., 2012,

    Independent Preoperative Predictors of Outcomes in Orthopedic and Vascular Surgery The Influence of Time Interval Between an Acute Coronary Syndrome or Stroke and the Operation

    , ANNALS OF SURGERY, Vol: 255, Pages: 901-907, ISSN: 0003-4932
  • Journal article
    Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P, Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, The GenISIS Investigators, The MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam P, Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, Everingham K, Dawson H, Hope D, Ramsay P, Campbell A, Kerr S, Harrison D, Rowan K, Addison J, Donald N, Galt S, Noble D, Taylor J, Webster LL, Taylor Local LI, Aldridge LL, Dornan R, Richard C, Gilmour D, Simmons LL, White LL, Jardine C, Williams LL, Booth LL, Quasim T, Watson V, Henry P, Munro F, Bell L, Ruddy LL, Cole LL, Southward J, Allcoat P, Gray S, McDougall LL, Matheson J, Whiteside LL, Alcorn D, Rooney LL, Sundaram R, Imrie LL, Bruce J, McGuigan K, Moultrie LL, Cairns LL, Grant J, Hughes M, Murdoch LL, Davidson LL, Harris G, Paterson R, Wallis LL, Binning LL, Pollock M, Antonelli J, Duncan A, Gibson J, McCulloch C, Murphy L, Haley C, Faulkner G, Freeman T, Hume DA, Baillie JK, Chaussabel D, Adamson WE, Carman WF, Thompson C, Zambon MC, Aylin P, Ashby D, Barclay WS, Brett SJ, Cookson WO, Drumright LN, Dunning J, Elderfield RA, Garcia-Alvarez L, Gazzard BG, Griffiths MJ, Habibi MS, Hansel TT, Herberg JA, Holmes AH, Hussell T, Johnston SL, Kon OM, Levin M, Moffatt MF, Nadel S, Openshaw PJ, Warner JO, Aston SJ, Gordon SB, Hay A, McCauleet al., 2012,

    IFITM3 restricts the morbidity and mortality associated with influenza.

    , Nature, Vol: 484, Pages: 519-523

    The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses1, 2, 3, 4, 5, 6, 7. Both the magnitude and breadth of the IFITM proteins’ in vitro effects suggest that they are critical for intrinsic resistance to such viruses, including influenza viruses. Using a knockout mouse model8, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 ‘Spanish’ influenza9, 10. Similar increased viral replication is seen in vitro, with protection rescued by the re-introduction of Ifitm3. To test the role of IFITM3 in human influenza virus infection, we assessed the IFITM3 alleles of individuals hospitalized with seasonal or pandemic influenza H1N1/09 viruses. We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

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