@article{Wang:2019:10.1002/bjs5.50135,
author = {Wang, Y and Honeyford, K and Aylin, P and Bottle, A and Giuliani, S},
doi = {10.1002/bjs5.50135},
journal = {BJS Open},
pages = {305--313},
title = {One-year outcomes for congenital diaphragmatic hernia},
url = {http://dx.doi.org/10.1002/bjs5.50135},
volume = {3},
year = {2019}
}

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TY  - JOUR
AB  - BackgroundCongenital diaphragmatic hernia (CDH) is a congenital anomaly with high mortality and longterm morbidity. The aim of this study was to benchmark trends in 1year and hospital volume outcomes for this condition.MethodsThis study included all infants born with CDH in England between 2003 and 2016. This was a retrospective analysis of the Hospital Episode Statistics database. The main outcomes were: 1year mortality, neonatal length of hospital stay (nLOS), total beddays at 1 year and readmission rate. The association between hospital volume and outcomes was assessed for specialist paediatric surgery centres.ResultsA total of 2336 infants were included (incidence 2·5 per 10 000 live births). No significant time trends were found in incidence and main outcomes. Some 1491 infants (63·8 per cent) underwent surgical repair. The 1year mortality rate was 31·2 per cent. Median nLOS and total beddays were 17 and 19 days respectively. The readmission rate in specialist paediatric centres was 6·3 per cent. Higher mortality was associated with birthweight lower than 1 kg (OR 5·90, 95 per cent c.i. 1·03 to 33·75), gestational age of 36 weeks or less (OR 1·75, 1·12 to 2·75) and black ethnicity (OR 2·13, 1·03 to 4·48). Only 4·0 per cent had extracorporeal membrane oxygenation, which was associated with higher mortality (OR 5·34, 3·01 to 9·46), longer nLOS (OR 3·70, 2·14 to 6·14) and longer total beddays (OR 3·87, 2·19 to 6·83). Specialist paediatric centres showed variation in 30day mortality (4·6 per cent with 84 per cent coefficient of variation), nLOS (median 25 (i.q.r. 15–42) days) and total beddays (median 28 (i.q.r. 16–51) days), but no significant volume–outcome relationship.ConclusionKey outcomes for CDH were similar to those of other develo
AU  - Wang,Y
AU  - Honeyford,K
AU  - Aylin,P
AU  - Bottle,A
AU  - Giuliani,S
DO  - 10.1002/bjs5.50135
EP  - 313
PY  - 2019///
SN  - 2474-9842
SP  - 305
TI  - One-year outcomes for congenital diaphragmatic hernia
T2  - BJS Open
UR  - http://dx.doi.org/10.1002/bjs5.50135
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000473810300008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71599
VL  - 3
ER  - 

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