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DTSTAMP:20260614T191832Z
SUMMARY:Evolutionary and structure/function analysis of host-targeted bacte
 rial effector proteins
DESCRIPTION:Abstract\nPathogenic bacteria often use dedicated protein secre
 tion machineries to translocate bacterial effector proteins into host cell
 s in order to manipulate cellular signaling pathways to their benefit. Pat
 hogens of the genus Bartonella that cause chronic blood infections in a wi
 de range of mammals have provided insights how such trans-kingdom protein 
 transfer systems and their translocated effectors have evolved from preexi
 sting bacterial structures\, and how they target specific host cellular si
 gnaling processes. The bartonellae employ for effector translocation so ca
 lled type IV secretion machineries that evolved from the bacterial conjuga
 tion machinery. Their diverse translocated effector sets evolved from a si
 ngle bacterial toxin-antitoxin module by multiple rounds of gene duplicati
 on and diversification. The effectors display multi-domain architectures t
 hat are composed of only three basic domain types that are highly versatil
 e in function. I will use a striking example of parallel evolution to illu
 strate emergence of convergent effectors sets in separate Bartonella linea
 ges. Moreover\, I will provide examples of how individual effector domains
  interfere with important host cell signaling processes.\nBiography\nProfe
 ssor Christoph Dehio received his Ph.D. in 1992 from the University of Col
 ogne in Germany. From 1993 to 1995\, he conducted postdoctoral research at
  Institut Pasteur in Paris. From 1995 to 2000\, he was research group lead
 er at the Max Planck Institute for Biology in Tübingen\, Germany. In 2000
 \, he joined the Biozentrum of the University of Basel\, Switzerland\, as 
 Tenure-Track Assistant Professor\, where he now holds the position of a Fu
 ll Professor of Molecular Microbiology and acts as Speaker of the Focal Ar
 ea Infection Biology.  \nProfessor Dehio is elected member of the German 
 Academy of Sciences Leopoldina (2010)\, EMBO (2013) and the European Acade
 my of Microbiology (2016). He was an International Research Scholar of the
  Howard Hughes Medical Institute (2005-2010) and member of the National Re
 search Council of the Swiss National Science Foundation (2009-2016).\nThe 
 research of Professor Dehio is dedicated to gaining a molecular understand
 ing of pathogen – host interaction underlying chronic bacterial infectio
 n. Using the chronically infecting intracellular pathogens Bartonella and 
 Brucella as models\, his research focuses on the specific contribution of 
 type IV secretion systems to bacterial pathogenesis and on the evolution o
 f these virulence devices for trans-kingdom protein transfer from genuine 
 bacterial conjugation systems mediating interbacterial DNA transfer.
URL:https://www.imperial.ac.uk/events/100337/evolutionary-and-structure-fun
 ction-analysis-of-host-targeted-bacterial-effector-proteins/
DTSTART;TZID=Europe/London:20170530T123000
DTEND;TZID=Europe/London:20170530T133000
LOCATION:United Kingdom
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