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SUMMARY:Andrea Weisse (Edinburgh): Mechanistic links between cellular trade
 -offs\, gene expression and growth
DESCRIPTION:Intracellular processes rarely work in isolation but continuall
 y interact with the rest of the cell. In microbes\, for example\, we now k
 now that gene expression across the whole genome typically changes with gr
 owth rate. The mechanisms driving such global regulation\, however\, are n
 ot well understood. Here we consider three trade-offs that\, because of li
 mitations in levels of cellular energy\, free ribosomes\, and proteins\, a
 re faced by all living cells. We construct a coarse-grained mechanistic mo
 del that comprises these trade-offs and describes how the cell imports and
  digests nutrients from the environment and how it uses the derived resour
 ces for gene expression and to drive growth. The model thus couples the ex
 pression of different types of genes with growth rate and growth rate with
  a growing population of cells. In this talk\, we discuss the essential pa
 rts of the model and show how it recovers the typical growth behaviour obs
 erved in microbial populations. We then show how the model can be used for
  applications in systems and synthetic biology. Last\, we consider a multi
 -scale version of the model to simulate competitions between populations o
 f cells in order to study evolutionary benefits of gene regulation.
URL:https://www.imperial.ac.uk/events/104281/mechanistic-links-between-cell
 ular-trade-offs-gene-expression-and-growth/
DTSTART;TZID=Europe/London:20150512T130000
DTEND;TZID=Europe/London:20150512T140000
LOCATION:130\, Huxley Building\, South Kensington Campus\, Imperial College
  London\, London\, SW7 2AZ\, United Kingdom
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