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DTSTAMP:20260503T064224Z
SUMMARY:Optogenetic dissection of sleep-wake circuits in the brain
DESCRIPTION:Abstract\nWhile the functions of sleep are still a matter of d
 ebate and may include memory consolidation and plasticity\, the neural su
 bstrates of sleep and wake states are the subject of intense study. Succ
 essive sleep-wake cycles rely on an appropriate balance between sleep-pro
 moting nuclei of the brain located in the anterior hypothalamus and\, ar
 ousal-promoting nuclei from the posterior hypothalamus and the brainstem 
 including the dopamine\, norepinephrine\, serotonin systems. We have inv
 estigated some of the neural substrates of arousal and REM sleep using a c
 ombination of electrophysiology and optogenetics in freely-moving mice. We
  recently demonstrated that a subset of hypothalamic cells expressing the
  peptide melanin-concentrating hormone (MCH) are both sufficient for the 
 induction of rapid-eye movement (REM) sleep (or paradoxical sleep)\, and 
 required for theta rhythm stability during REM sleep. We further identif
 ied a subset of inhibitory cells from the same hypothalamus area that dire
 ctly control the activity of the reticular thalamus nuclei and induce arou
 sal through feed-forward disinhibition of thalami-cortical loop during NRE
 M\, but not REM sleep. This lecture will present these recent work and pro
 posed an integrated model of hypothalamic regulation of sleep-wake states\
 , as well as consciousness.
URL:https://www.imperial.ac.uk/events/104538/optogenetic-dissection-of-slee
 p-wake-circuits-in-the-brain/
DTSTART;TZID=Europe/London:20151125T170000
DTEND;TZID=Europe/London:20151125T180000
LOCATION:United Kingdom
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