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SUMMARY:Dr Ryan Pedrigi from Imperial College London
DESCRIPTION:Abstract\nThin-cap fibroatheroma (TCFA) is an atherosclerotic p
 laque type most vulnerable to rupture\, which is the leading cause of deat
 h in coronary heart disease. Atherosclerosis is initiated by endothelial c
 ell dysfunction and it has long been recognized that the hemodynamic envir
 onment\, typically quantified via shear stress\, may play an important rol
 e in promoting a pro-atherogenic cell phenotype. Despite numerous studies\
 , there is no consensus on the relationship between disturbed flow and mar
 kers of atherogenesis or specific advanced plaque morphologies such as TCF
 A. To study this relationship in greater detail\, we have developed custom
  software that accurately co-registers in vivo images with histological da
 ta in 3-D (called 3-D histology). Computational fluid dynamics is then per
 formed on vessel geometries derived from the in vivo images to compute est
 ablished and new shear stress metrics of disturbed flow. The overlap is th
 en computed between these shear metrics and histopathological markers of a
 therosclerosis at a high spatial resolution. We applied this framework to 
 a hypercholesterolemic mouse carotid and pig coronary model of atheroscler
 osis\, wherein\, for each\, an instrument was surgically introduced that p
 erturbed the vessel hemodynamics and induced TCFA formation. We found that
  TCFA consistently formed within local regions of low shear stress\, which
  we quantified with a new metric called the low shear index. Future work w
 ill use this framework to isolate dysfunctional endothelial cells from loc
 al regions exhibiting a high magnitude of low shear index to better unders
 tand the altered genomics that underlies the patho-mechanobiology of TCFA.
 \nTo learn more about this speaker\, please visit his university webpage.
  
URL:https://www.imperial.ac.uk/events/105304/dr-ryan-pedrigi-from-imperial-
 college-london/
DTSTART;TZID=Europe/London:20150305T120000
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LOCATION:United Kingdom
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