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DTSTAMP:20260506T215929Z
SUMMARY:The Biomechanics of Lymphatic System Pumping
DESCRIPTION:Abstract\nThe lymphatic system is an extensive vessel network f
 eaturing one-way valves and contractile walls that pump interstitial fluid
 \, proteins\, and immune cells through lymph nodes and then back to the bl
 ood circulation. This system is crucial in immune response\, as well as be
 ing the pathway of distribution for metastatic tumor cells.  Failure to d
 rain and pump results in oedema\, or fluid retention and swelling. \nWe a
 re developing multi-scale computational models of lymphatic function from 
 the sub-cellular to the whole organ level in conjunction with a series of 
 experiments. Models of vessel segments in series have been characterized t
 hrough pump curves of steady pressure difference versus flow rate.  These
  curves exhibit non-linear behaviors typical of mixed source pumps.  Thes
 e models also provide the opportunity to quantify the importance of variou
 s modeling parameters through sensitivity analysis.  For example\, the ph
 ase angle between successive lymphangion contractions is an important dete
 rminant of pumping efficiency\, with out-of-phase behavior being the most 
 efficient. \nExperiments with rat mesentery lymphatics revealed that thes
 e vessels quickly adapted to increased volume loads by increasing lymph fl
 ow rate and contraction frequencies. Valves are biased toward the open pos
 ition\, with that bias increasing with transmural pressure. \nUnlike arte
 rial and venous vessels\, the lymphatic system has not been the subject of
  extensive modelling efforts.  Our work is aimed at constructing models t
 hat strike a delicate balance between the need to represent complex physio
 logical phenomena and the desire to keep the modelling feasible computatio
 nally. 
URL:https://www.imperial.ac.uk/events/108993/the-biomechanics-of-lymphatic-
 system-pumping/
DTSTART;TZID=Europe/London:20130228T130000
DTEND;TZID=Europe/London:20130228T140000
LOCATION:United Kingdom
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