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DTSTAMP:20260513T174009Z
SUMMARY:Polyamine biosynthesis and translational frameshifting in yeast: ch
 aracterising a cellular feedback
DESCRIPTION:Abstract \nThe polyamine molecules putrescine\, spermidine and
  spermine are involved in a number of important cellular processes such as
  transcriptional silencing\, translation\, protection from reactive oxygen
  species and coenzyme A synthesis. Components of the polyamine pathway are
  also potential targets for cancer therapeutics\, as unregulated polyamine
  synthesis can trigger uncontrolled cell proliferation. Conversely\, polya
 mine depletion can cause apoptosis\, and during development\, defects lead
 ing to mental retardation in humans (Snyder-Robinson Syndrome). Controllin
 g polyamine concentrations is thus a significant regulatory challenge for 
 the cell\, because there are multiple cellular requirements for polyamines
  as well as a need to homeostatically maintain their concentration within 
 a certain non-toxic range. In the cell\, polyamine concentrations are regu
 lated by multiple mechanisms\, the most important of which is a feedback c
 ontrol loop involving Spe1 (the enzyme catalysing the first step in the po
 lyamine biosynthesis pathway) and the protein antizyme\, which is synthesi
 sed via a +1 ribosomal frameshift during translation of the antizyme mRNA.
  In this talk I will present the first predictive model of the polyamine 
 feedback controller\, which has been developed and validated using a Syste
 ms Biology approach incorporating enzyme kinetics\, control engineering a
 nd experimental molecular biology.
URL:https://www.imperial.ac.uk/events/111402/polyamine-biosynthesis-and-tra
 nslational-frameshifting-in-yeast-characterising-a-cellular-feedback/
DTSTART;TZID=Europe/London:20111115T160000
DTEND;TZID=Europe/London:20111115T170000
LOCATION:United Kingdom
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