This webinar will be held on zoom. The stucture of the event will be a presentation followed by audience Q&A. Please register to be sent the joining instructions. You can pre-submit questions for the Q&A section when registering.

This webinar is part of the series

Vaccines: Development, Manufacturing and Distribution

The theme discussed in this webinar will be:

Quality by digital design and techno-economic modelling of RNA vaccine production for pandemic response

Abstract

The RNA vaccine platform technology has been successfully used to develop Covid-19 vaccines at record speeds. However, the RNA vaccine production volumes and rates can be further increased, while reducing costs and maintaining consistently high product quality. To aid this, we perform quality by digital design (QbDD) and techno-economic modelling of the RNA vaccine production process. In the QbDD framework, first-principle or data-driven relationships are established between the critical process parameters (CPPs) of the production process and the critical quality attributes (CQAs) of the RNA vaccine product. The obtained models can be used for defining the design space and for advanced automation using model-predictive control. By combining the QbDD model with the RNA vaccine platform, vaccines and candidate vaccines can be developed and mass-produced faster against virtually any viral disease. Techno-economic modelling supports production process de-bottlenecking and identification of optimal RNA vaccine production process configurations for a rapid pandemic response.

Biography

Dr. Zoltán Kis

Research Associate in the Department of Chemical Engineering

Dr. Zoltán Kis is a Lecturer at the Department of Chemical and Biological Engineering at The University of Sheffield.

Zoltán is developing and modelling rapid-response vaccine production platform technologies, such as the RNA platform. This work is addressing the challenge of producing large volumes of vaccines, rapidly, at high quality and at low cost for pandemic-response.

Zoltán has previously worked as a Research Associate in the Future Vaccine Manufacturing Hub at the Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London. He obtained his Ph.D. in Bioengineering from Imperial College London, UK, holds an M.Sc. in Applied Biotechnology and a B.Eng. in Chemical with Biochemical Engineering.

More events in the “Vaccines: Development, Manufacturing and Distribution” Series

• 30 September 14.00 Nanoformulations for Targeted Vaccine Delivery and Stable Storage at Ambient Temperatures presented by Dr. Rongjun Chen
• 7 October 14.00 Quality by digital design and techno-economic modelling of RNA vaccine production for pandemic response presented by Dr. Zoltán Kis
• 21 October 14.00 Forecasting COVID-19 uptake in the UK and monitoring attitudes to COVID-19 vaccines presented by Dr. Alexandre De Figueiredo
• 28 October 14.00 Digital Tools in Bioprocess Design and Optimisation presented by Dr. Maria Papathanasiou

About The Institute for Molecular Science and Engineering

The Institute for Molecular Science and Engineering (IMSE) is one of Imperial College London’s Global Institutes, drawing on the strength of its four faculties to address some of the grand challenges facing the world today. The Institute’s activities are focused on tackling problems where molecular innovation plays an important role.

If you have any questions about accessibility requirements please email Leah Adamson (IMSE Events Officer) on l.adamson@imperial.ac.uk