The team “Pathogenesis and Commensalism of Enterobacteria”, headed by Eric Oswald, integrates human and animal researches to decipher the thin-line between commensal and pathogenic enterobacteria and their role in modulating the host cell cycle, genomic integrity, physiology and metabolism. In order to achieve this goal, new scientific and technological knowledges have been acquired in different aspects of enterobacterial infection, gut colonization and ecology. The team is working on several Escherichia coli pathotypes such as enteropathogenic and hemorrhagic or extra-intestinal pathogenic E. coli (EPEC and EHEC or ExPEC) but also on commensal and probiotic E. coli as well as gut microbiota dysbiosis and its impact in infection, metabolic diseases and carcinogenesis. The team develops a multidisciplinary approach, including methodologies from microbiology, molecular biology, immunology, cell biology, metagenomic, integrated physiology as well as animal models to study the:

  1. Carriage and dissemination of pathogenic and antibiotic-resistant enterobacteria.
  2. Genotoxins, siderophores and microcines in infectious diseases and cancer development.
  3. Outer Membrane Vesicles: pathogenicity, vaccine and immunotherapy.
  4. Microbiota and pathobionts in metabolic and inflammatory diseases.

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