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UID:eec04e58262ca5af1d0f0b31c34e6240
DTSTAMP:20260921T115937Z
SUMMARY:Heterogeneous drug accumulation in cancer: why concentration matter
 s
DESCRIPTION:Therapeutic options in cancer have improved dramatically in rec
 ently years\, but unfortunately\, resistance remains a major clinical hurd
 le. While numerous genetic and non-genetic factors are emerging as importa
 nt mediators\, pharmacological factors determining both intrinsic and acqu
 ired resistance remain under-explored. \nWe are interested in whether diff
 erential drug accumulation at the cellular level could be a factor determi
 ning inter-patient heterogeneity in drug response. Similarly\, we are expl
 oring how drug accumula)on varies within a patient’s tumour\, and wheth
 er pockets of low drug accumula)on can give rise to drug resistance.\n H
 ere\, I will discuss our use of multi-modal tissue imaging to explore this
  idea in in ovarian High Grade Serous Carcinoma patient-derived explants. 
 We examined the distribution of three clinically used PARP inhibitors usin
 g mass spectrometry imaging\, and used spatial transcriptomics to investi
 gate both the molecular factors driving differential accumulation and its 
 consequences for drug response. We have observed substantial heterogeneity
  in drug distribution both within and between tumours\, and both this hete
 rogeneity its implications for drug response are recapitulated at the sing
 le cell level in cell lines\, enabling a deeper exploration of underlying 
 mechanisms.
URL:https://www.imperial.ac.uk/events/196846/heterogeneous-drug-accumulatio
 n-in-cancer-why-concentration-matters/
DTSTART;TZID=Europe/London:20250911T150000
DTEND;TZID=Europe/London:20250911T160000
LOCATION:The IRDB Seminar Room\, Ground floor\, The IRDB Building\, Institu
 te Of Reproductive and Developmental Biology (IRDB)\, Hammersmith Campus\,
  Imperial College London\, London \, W12 0NN\, United Kingdom
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