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SUMMARY:Converging on Cancer: International Seminar Series – Prof Holger 
 Auner (University Hospital Luasanne) and Assoc Prof Morten Frödin (BRIC 
 – University of Copenhagen)
DESCRIPTION:The CRUK Convergence Science Centre is a partnership between Im
 perial College London and The Institute of Cancer Research. In collaborati
 on with our international partners we arrange a regular international semi
 nar ‘Converging on Cancer’ on the topic of interdisciplinary cancer re
 search. Our partners are:\n\nTechnical University of Munich (TUM)\nNanyang
  Technological University (NTU)\nBiotech Research and Innovation Centre (B
 RIC – University of Copenhagen)\nÉcole Polytechnique Fédérale de Laus
 anne (EPFL).\n\n\nIn this series\, we bring together speakers from across 
 these institutions to present their research and how they use convergence 
 science to answer cancer-related questions.\nThis session will be chaired 
 by Assoc Prof Claus Storgaard Sørensen\, BRIC – University of Copenh
 agen. \n\nThursday 4th September\, 10-11am BST\, 11-12pm CEST\, 5-6pm SGT
 \n\nSpeakers\nProf Holger Auner (Lausanne University Hospital)\nTargeting
  proteostasis and translation control in hematopoietic and solid cancers\n
 In this seminar\, Holger Auner will discuss recent and ongoing work in his
  lab on the role of the Integrated Stress Response (ISR) and GCN2\, a high
 ly conserved kinase that enables cells to adapt to various forms of proteo
 static stress\, such as the amino acid shortages caused by proteasome inhi
 bition. He will present new insights into how cancer cells rely on GCN2 to
  regulate protein synthesis and maintain metabolic homeostasis — and how
  this dependency can be exploited as a potential therapeutic vulnerability
 . \nAssoc Prof Morten Frödin (BRIC – University of Copenhagen)\nCRIS
 PR-Select: A fast\, accurate and versatile functional-genetic assay to dis
 sect the roles genes and variants/mutations in cancer\nThis talk will intr
 oduce CRISPR-Select\, a simple and powerful functional-genetic assay for d
 issecting the roles of genes and mutations in cellular model systems. CRIS
 PR-Select has been used to probe roles of genes (by introducing STOP varia
 nt)\, pathogenicity/driver roles of variants-of-uncertain-significance (VU
 S) in cancer genes\, variant drug responsiveness/resistance\, importance o
 f phosphorylation/ubiquitination sites or in vivo tumor promotion by speci
 fic variants/cancer genes. Mechanistically\, CRISPR-Select can dissect how
  a variant elicits a phenotype by causally linking the variant to motility
 /invasiveness or any cell state or biochemical process with a flow cytomet
 ry marker. The method is applicable to organoids\, primary cells\, non-tra
 nsformed or cancer cell lines and we have scaled it for automated\, higher
 -throughput 96-well plate format. Altogether\, CRISPR-Select provides a ve
 rsatile functional variant assay for research\, diagnostics and drug devel
 opment in cancer and other genetic disorders.\n \nWho can attend?\nResear
 chers\, students and anyone with an interest in convergence science relati
 ng to cancer research across our partnered institutions are welcome to r
 egister:\n\nCRUK Convergence Science Centre\nImperial College London\nThe 
 Institute of Cancer Research (ICR)\nTechnical University of Munich (TUM)\n
 Nanyang Technological University (NTU)\nBiotech Research and Innovation Ce
 ntre (BRIC – University of Copenhagen)\nÉcole Polytechnique Fédérale 
 de Lausanne (EPFL)\nCRUK Cambridge Centre\nCRUK City of London Centre (Kin
 gs college\, UCL\, Barts Cancer Institute/Queen Mary University\, Francis 
 Crick)\nCRUK Manchester Centre\nCRUK Newcastle Centre\nCRUK Oxford Centre\
 nCRUK Scotland Centre (University of Edinburgh and University of Glasgow)\
 n\n \nEmail icr-imperial-convergence.centre@imperial.ac.uk to receive the
  registration link and joining details.\n 
URL:https://www.imperial.ac.uk/events/200336/converging-on-cancer-internati
 onal-seminar-series-prof-holger-auner-university-hospital-luasanne-and-ass
 oc-prof-morten-frodin-bric-university-of-copenhagen/
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