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UID:e870962ff548e172bf7696a584aa64c9
DTSTAMP:20260503T160052Z
SUMMARY:Bacterial metabolite sharing emerges from a balance between release
  and uptake
DESCRIPTION:Abstract:\nMicrobial communities are shaped by environmental co
 nditions and ecological interactions\, but the mechanisms underlying these
  interactions often remain unclear. In many cases\, these can be understoo
 d mechanistically as being mediated by external metabolite pools. Vitamin 
 B12 is a particularly consequential example: it is produced by relatively 
 few prokaryotes\, used by many bacteria\, and required by over half of alg
 al species\, linking bacterial provisioning to primary productivity in aqu
 atic systems. Here\, I ask how B12 is provisioned by bacterial producers a
 nd what determines the size of extracellular B12 pools. To address this\, 
 we quantified B12 synthesis\, release\, and uptake across hundreds of bact
 erial isolates from terrestrial and marine environments. Four broad strate
 gies emerged: Retainers (synthesis and high uptake)\, Providers (synthesis
  and no uptake)\, Scavengers (no synthesis\, high uptake)\, and Bystanders
  (no synthesis and no uptake). For individual taxa\, extracellular B12 con
 centrations could be quantitatively predicted from release during cell lys
 is together with reuptake by the remaining living cells\, suggesting that 
 extracellular B12 pools reflect a flux balance between passive release and
  subsequent uptake. In this view\, reuptake by producers is a major contro
 l on the size of extracellular metabolite pools and thus on the degree of 
 metabolite sharing.
URL:https://www.imperial.ac.uk/events/208525/bacterial-metabolite-sharing-e
 merges-from-a-balance-between-release-and-uptake/
DTSTART;TZID=Europe/London:20260618T130000
DTEND;TZID=Europe/London:20260618T140000
LOCATION:Oak/Birch lecture theatre\, Hamilton Building\, Silwood Park Campu
 s\, Imperial College London\, Berkshire\, SL5 7PY\, United Kingdom
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DTSTART:20260618T130000
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