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SUMMARY:Converging on Cancer: Dr Anke Nijhuis and Dr Sally George
DESCRIPTION:The CRUK Convergence Science Centre is a partnership between Im
 perial College London and The Institute of Cancer Research (ICR). We aim t
 o bring together researchers from different disciplines across both instit
 utions to develop innovative ways to address challenges in cancer research
  to benefit patients. \nThis seminar series brings together speakers from
  Imperial and ICR to present their research and how they use convergence 
 science to answer cancer-related questions.\nThis session will explore adv
 ances in precision medicine and targeted cancer biology relevant to paedia
 tric cancers.\n \nDr Anke Nijhuis (Imperial)\nDrugging the spliceosome wi
 th molecular glue degraders of RBM39 in cancer\nRNA splicing is an essenti
 al step in gene expression that is frequently dysregulated in cancer\, cre
 ating a therapeutic vulnerability that remains largely untapped in the cli
 nic. The splicing factor RBM39 has emerged as a particularly attractive ta
 rget\, as it can be selectively depleted by aryl sulfonamide molecular glu
 e degraders\, which redirect the CRL4-DCAF15 ubiquitin ligase to ubiquitin
 ate and degrade RBM39. Loss of RBM39 produces widespread aberrant splicing
 \, disrupting transcripts essential for tumour cell survival. I will share
  recent work from my group on the sensitivity of MYCN-driven tumours to RB
 M39 degradation\, and on how interference with RNA splicing disrupts DNA d
 amage repair and modulates the immune system. I will also discuss how we u
 se these insights to rationally design combinatorial approaches to improve
  treatment responses.\n \nDr Sally George (ICR)\nThe Stratified Medicine 
 Paediatrics Precision Medicine Programme for children with cancer\nStratif
 ied Medicine Paediatrics (SMPaeds) is a national precision medicine progra
 mme for children with cancer aiming to develop and validate biomarker assa
 ys in the research setting then transfer them into the NHS. I will discuss
  what we learned from SMPaeds1 and how that has informed the design of the
  SMPaeds2 clinical trial which is currently recruiting.\n \nWho can atten
 d?\nResearchers\, students and anyone with an interest in convergence scie
 nce relating to cancer research across Imperial and ICR are welcome to r
 egister. Please email icr-imperial-convergence.centre@imperial.ac.uk to re
 ceive the registration link.\n 
URL:https://www.imperial.ac.uk/events/209309/converging-on-cancer-dr-anke-n
 ijhuis-and-dr-sally-george/
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LOCATION:United Kingdom
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