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UID:991c359838f6d4f1ab8bf062fc5a9d71
DTSTAMP:20260506T190353Z
SUMMARY:Bioengineering Department Seminar with Dr Guosong Hong
DESCRIPTION:PLEASE NOTE: \n\nThis seminar is IN PERSON ONLY in room RSM 
 2.28\, Second Floor\, Royal School of Mines at Imperial’s South Kensingt
 on campus.\nClick here for the South Kensington campus map.\n\n\nGUEST SPE
 AKER: \nDr Guosong Hong\, Assistant Professor of Materials Science and En
 gineering\, Stanford University\nTALK TITLE: \nSeeing the Invisible: From
  Ultrasound-Activated Light to Transparency in Mice\nABSTRACT:\nLight play
 s a central role in science\, shaping both how we study living systems and
  how we perceive the world around us. As we observe in daily life\, light 
 has difficulty penetrating living biology tissue\, mainly because of scatt
 ering and absorption. This limitation hampers the use of light in biologic
 al research\, often necessitating invasive procedures such as tissue secti
 oning\, insertion of optical fibers or endoscopes\, and surgical removal o
 f overlying structures (e.g.\, craniotomy) to modulate and image biologica
 l activity using light microscopy.\nTo address these challenges\, my lab h
 as developed several methods for deep-tissue light delivery and optical im
 aging. First\, we leveraged defect engineering to synthesize trap-controll
 ed mechanoluminescent materials as an ultrasound-scanning in vivo light so
 urce. When formulated as colloids\, these materials can be delivered intra
 venously and emit light locally at the ultrasound focus. This approach ena
 bles on-demand and dynamically programmable light emission patterns at sub
 stantial tissue depths in a noninvasive manner\, facilitating a wide range
  of light-based applications in live animals by harnessing the deep-tissue
  penetration of focused ultrasound.\nFurthermore\, we recently developed a
  new approach to achieve optical transparency in live animals by leveragin
 g the Kramers-Kronig relations in absorbing dye molecules\, which enables 
 effective modulation of the refractive index within biological tissues. We
  demonstrated that tissues in living rodents can be rendered optically tra
 nsparent in a reversible and repeatable manner through the application of 
 these dye molecules.\nI will conclude my talk by envisioning an invisible 
 future — one in which advances in physics\, chemistry\, and materials sc
 ience transform biological imaging and light-based therapies.\nBIOGRAPHY:\
 nDr Guosong Hong received his PhD in chemistry from Stanford University in
  2014 and then carried out postdoctoral studies at Harvard University. Dr 
 Hong joined Stanford Materials Science and Engineering and the Neuroscienc
 es Institute as an assistant professor in September 2018.\nHis research at
  Stanford aims to develop and apply novel optical and electronic materials
  for minimally invasive brain interfacing.\nHe is a recipient of the NIH P
 athway to Independence (K99/R00) Award\, the MIT Technology Review ‘35 I
 nnovators Under 35’ Award\, the Science PINS Prize for Neuromodulation\,
  the NSF CAREER Award\, the Walter J. Gores Award for Excellence in Teachi
 ng\, the Rita Allen Foundation Scholars Award\, the Camille Dreyfus Teache
 r-Scholars Award\, ETH Zürich Materials Research Prize for Young Research
 ers\, the Presidential Early Career Award for Scientists and Engineers (PE
 CASE)\, the Vilcek Prize for Creative Promise in Biomedical Science\, the 
 SPIE Inaugural Biophotonics Discovery Impact of the Year Award\, the Sloan
  Research Fellowship\, and the Maximizing Innovation in Neuroscience Resea
 rch (MIND) Prize. He has also recently been elected to the College of Fell
 ows of the American Institute for Medical and Biological Engineering (AIMB
 E).
URL:https://www.imperial.ac.uk/events/209328/bioengineering-department-semi
 nar-with-dr-guosong-hong/
DTSTART;TZID=Europe/London:20260513T140000
DTEND;TZID=Europe/London:20260513T150000
LOCATION:RSM 2.28\, Second Floor\, Royal School Of Mines\, South Kensington
  Campus\, Imperial College London\, London\, SW7 2AZ\, United Kingdom
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