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DTSTAMP:20260521T222719Z
SUMMARY:Early Academic Talks (EAT)
DESCRIPTION:We are hosting our next Early Academic Talks session this mon
 th on Thursday 30th April. This is a great opportunity for Early Career R
 esearchers (ECRs) to network and learn about the research at Imperial in a
  friendly and informal environment. \n\n\n\n\nHanh Duyen Tran\, PhD Stude
 nt \n\n\nModelling G protein biased agonism using glucagon-like peptide-1
  receptor (GLP-1R) C-terminal modifications \n\n\n \n\n\nBiased GLP-1R a
 gonists such as tirzepatide and orfoglipron demonstrate better clinical ou
 tcomes than earlier monoagonists like semaglutide\, yet the full impact of
  biased agonism remains difficult to study due to variations in how differ
 ent ligands behave pharmacokinetically. To address this\, targeted mutatio
 ns introduced into the receptor’s C-terminal tail generate a receptor-ba
 sed model that recapitulates G protein biased agonism\, enabling precise c
 haracterisation of this signalling phenomenon without the need for ligand 
 modifications.\n\n\n\n\n\n\n\n
URL:https://www.imperial.ac.uk/events/209765/early-academic-talks-eat-9/
DTSTART;TZID=Europe/London:20260528T161000
DTEND;TZID=Europe/London:20260528T170000
LOCATION:SB Seminar Room 10A\, Commonwealth Building\, Hammersmith Campus\,
  Imperial College London\, London \, W12 0NN\, United Kingdom
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