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UID:597bd05fde24369aa5e2af208e91ae94
DTSTAMP:20260716T221445Z
SUMMARY:Biomathematics seminar – Hollie Hindley (University of Edinburgh)
DESCRIPTION:Title: Heterogeneity in responses to ribosome-targeting antibio
 tics mediated by bacterial RNA repair.\n\nAbstract: RNA repair is critical
  for cellular function. The Rtc system maintains RNA integrity within the 
 translational machinery of bacteria. In E. coli\, Rtc expression enables c
 ells to rescue growth and survive treatment by conferring transient resist
 ance to ribosome-targeting antibiotics\, yet the mechanisms underpinning t
 his resistance remain obscure. Here\, we present a computational model of 
 Rtc-regulated repair of translational RNAs. Integrating model predictions 
 with experimental validations\, we uncover notable cell-to-cell heterogene
 ity in rtc expression that impacts on translational capacity\, indicating 
 that rtc may induce a form of heteroresistance. We moreover identify Rtc t
 argets that may reduce the translational capacity of cells and so potentia
 te antibiotic effects. Our findings elucidate a complex response underpinn
 ing resistance conferred by Rtc\, offering alternate routes for addressing
  resistance in E. coli and other relevant pathogens.
URL:https://www.imperial.ac.uk/events/210846/biomathematics-seminar-hollie-
 hindley-university-of-edinburgh/
DTSTART;TZID=Europe/London:20260622T130000
DTEND;TZID=Europe/London:20260622T140000
LOCATION:658\, Huxley Building\, South Kensington Campus\, Imperial College
  London\, London\, SW7 2AZ\, United Kingdom
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