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UID:4b0637bb7a7a639419bd5278f2708145
DTSTAMP:20261025T070630Z
SUMMARY:Sex-specific Innate Immune Networks of the Cystic Fibrosis Airway
DESCRIPTION:Dr. Britto is an Associate Professor of Medicine in the Divisio
 n of Pulmonary\, Critical Care & Sleep Medicine (PCCM) at Yale University\
 , School of Medicine\, the Director of the PCCM fellowship Program\, and t
 he Associate Director of The Yale Adult CF Program. \nHis research program
  investigates the role of airway immune cells in inflammatory signaling du
 ring host pathogen interactions\, with an emphasis on mononuclear phagocyt
 e communication in cystic fibrosis (CF). \n His laboratory applies a mult
 idisciplinary approach to understand excessive inflammation in CF airways\
 , focused on immune-epithelial interactions and respiratory infection. Dr.
  Britto performed the first single-cell CyTOF characterization of sputum i
 mmune cells in CF\, followed by the first scRNAseq characterization of air
 way immune cells in CF. His work uncovered a dysfunctional spectrum of inn
 ate immune activation\, maturation\, and cell survival in the transcriptio
 nal programs of airway immune cells\, likely to contribute to CF lung dise
 ase pathogenesis. \nHe currently focuses on investigating the role of sex-
 specific immune transcriptional networks as determinants of CF pathogenesi
 s and on dissecting the interplay of genomic factors\, sex hormones\, and 
 CFTR modulators in severe disease phenotypes and therapy response. \n \n
 RSVP to Ms. Liz Owen\nLiz.owen@imperial.ac.uk 
URL:https://www.imperial.ac.uk/events/212892/sex-specific-innate-immune-net
 works-of-the-cystic-fibrosis-airway/
DTSTART;TZID=Europe/London:20260914T160000
DTEND;TZID=Europe/London:20260914T170000
LOCATION:Paul Woods Lecture Theatre\, Guy Scadding Building\, Royal Brompto
 n Campus\, Imperial College London\, London\, SW3 6LY\, United Kingdom
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