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UID:69c8f570e6bec03cc6359cd6f90bba1b
DTSTAMP:20261008T000627Z
SUMMARY:Min Kyung Shinn: Nuclear speckles organisation by multi-domain RNA 
 binding proteins as block copolymers
DESCRIPTION:\nNuclear speckles organisation by multi-domain RNA binding pro
 teins as block copolymers \n\nThe phase behaviour of multi-domain protein
 s can be driven by specific patterns of inter-domain interactions among th
 e folded domains and intrinsically disordered regions (IDRs). The nuclear 
 speckle-associated serine/arginine-rich splicing factors (SRSFs) are RNA b
 inding proteins with one or two pairs of folded RNA recognition motifs and
  IDRs with characteristic serine/arginine repeats. We find that the SRSF f
 amily proteins are a unique archetype of block copolymers with attractive 
 RRM-IDR interactions and repulsive RRM-RRM and IDR-IDR interactions. The i
 nterplay of these interactions drives microphase separation of SRSF1 and t
 he formation of ordered\, size-limited assemblies of 23-45 nm in diameter\
 , each comprising tens of molecules. The cognate long non-coding RNA\, MA
 LAT1\, promotes SRSF1 microphase separation and regulates SRSF1 interactio
 ns with coding regions towards a model for the role of SRSF1 condensates i
 n facilitating co-transcriptional splicing of pre-mRNA. \n
URL:https://www.imperial.ac.uk/events/214374/shinn_speckles/
DTSTART;TZID=Europe/London:20261120T150000
DTEND;TZID=Europe/London:20261120T160000
LOCATION:RSM 303\, Royal School Of Mines\, South Kensington Campus\, Imperi
 al College London\, London\, SW7 2AZ\, United Kingdom
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