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DTSTAMP:20261105T173356Z
SUMMARY:Biomathematics seminar – Alejandro Torres-Sánchez (EMBL-Barcelon
 a)
DESCRIPTION:Can one see a force? Inferring mechanics from images of cells a
 nd tissues\n\nMechanical forces shape cells and tissues: they drive morpho
 genesis\, act as cues that cells sense and respond to\, and determine whet
 her tissues hold together or fail. Measuring these forces where they act\,
  however\, remains difficult. The probes that measure them directly\, such
  as indenters\, laser cuts\, molecular tension sensors and engineered subs
 trates\, perturb the system\, give local or relative readouts\, or require
  cells to sit on an artificial substrate\, and most cannot reach a cell in
 side a tissue or a living embryo. Images\, by contrast\, are now abundant:
  three-dimensional\, time-resolved\, and down to nanometre resolution. Inf
 erring forces from images is often the only way to map them where they act
 \, inside tissues and embryos.\n\nBut images record shapes and deformation
 s\, not forces\, and turning one into the other means inverting a physical
  model. In this talk I will discuss when that inversion is possible and wh
 at it takes. In a few favourable cases\, such as pressurised epithelia\, g
 eometry alone determines the forces. In others\, such as malaria-infected 
 red blood cells adhering to the endothelium\, knowing beforehand how the m
 aterial responds and being able to register its deformation allow us to re
 cover the forces. In general neither holds: the unknowns\, often the mater
 ial laws themselves\, can only be reached by solving the governing equatio
 ns many times and comparing the result with the data. I will present EchoE
 x\, a differentiable simulation framework built on JAX that makes such inv
 erse problems routine\, and illustrate it by inferring the mechanics of th
 e actin cable during zebrafish gastrulation from live imaging.
URL:https://www.imperial.ac.uk/events/216139/biomathematics-seminar-alejand
 ro-torres-sanchez-embl-barcelona/
DTSTART;TZID=Europe/London:20261109T130000
DTEND;TZID=Europe/London:20261109T140000
LOCATION:140\, Huxley Building\, South Kensington Campus\, Imperial College
  London\, London\, SW7 2AZ\, United Kingdom
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