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DTSTAMP:20260605T101955Z
SUMMARY:Tissue-engineering the neural interface
DESCRIPTION:Abstract\nOver the past 30 years implantable bionic devices suc
 h as cochlear implants and pacemakers\, have used a small number of metal 
 electrodes to restore sensory perception or muscle control to patients fol
 lowing disease or injury of excitable tissues. With the miniaturisation of
  electronic chips\, bionic devices are now being developed to treat a wide
  variety of neural and muscular disorders. Of particular interest is the a
 rea of high resolution devices that require smaller\, more densely packed 
 electrodes. Due to poor integration with living tissue\, conventional meta
 llic electrodes cannot meet these small size requirements and are limited 
 in their ability to safely deliver charge at therapeutic levels. \n\n \n
 A range of alternate electrode coating materials have been investigated by
  Dr Green including conductive hydrogels (CHs)\, conductive elastomers (CE
 s) and living electrodes (LEs) which provide synergy between low impedance
  charge transfer\, reduced stiffness and an ability to be provide a biolog
 ically active interface. While these approaches have initially been used t
 o modify existing implant electrodes (including cochlear implants and bion
 ics eye arrays)\, these technologies also offer new opportunities for prod
 ucing fully organic electrode arrays which are not bound to metallic subst
 rates. This talk will outline materials development and characterisation o
 f both in vitro properties and translational in vivo performance. The chal
 lenges for translation and commercial uptake of novel technologies will al
 so be discussed.\n \nBiography\nDr. Rylie Green joined the Bioengineering
  department at Imperial College London in 2016. She received her Ph.D. (Bi
 omedical Engineering) from the University of New South Wales\, Australia i
 n 2008. Dr. Green’s research has been broadly focused on developing medi
 cal electrodes\, with a specific focus on neuroprostheses. Her research is
  split into two related streams (i) biomaterials and tissue engineering\; 
 and (ii) bionics and device design. While Dr. Green’s research has been 
 focused on developing bioactive conducting polymers to improve performance
  of stimulating electrodes\, she has also developed a range of techniques 
 for characterising the in vitro performance of implantable microelectrodes
  in biologically relevant environments. Specifically\, she has investigate
 d electrode technologies for the developmental bionic eye device (with Bio
 nic Vision Australia)\, and coatings for commercial implants (with Cochlea
 r Ltd\, Galvani Bioelectronics and Boston Scientific). More recently Dr. G
 reen has developed hybrids of conducting polymers and hydrogels to reduce 
 strain mismatch with neural tissue and improve long-term cell interactions
  at the neural interface. This has led to her development of tissue engine
 ered “living electrodes”\, a new concept which will allow neural cells
  to synaptically interface with bionic devices.
URL:https://www.imperial.ac.uk/events/97645/tissue-engineering-the-neural-i
 nterface/
DTSTART;TZID=Europe/London:20190501T160000
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LOCATION:United Kingdom
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