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SUMMARY:Professor George A. O’ Doherty\,  Northeastern University\, Bosto
 n\, MA
DESCRIPTION:De Novo Asymmetric Approaches to Carbohydrate and Natural Produ
 ct Motifs for Stereochemical Structure Activity Relationship studies (S-SA
 R)\nAbstract: Over the years\, the O’Doherty group has been working to d
 evelop practical catalytic asymmetric approaches to the synthesis and stud
 y of stereochemically complex structural motifs. The unifying theme that c
 onnects our research in these two areas is our method of synthesis (asymme
 tric catalysis) and target selection (stereochemically complexity and biol
 ogical activity). A recurring theme in the group’s synthetic approaches 
 to any target is the reliance on asymmetric catalysis and synthetic design
  for the control of asymmetry. The application of these “atom economical
 ” approaches should allow simple conversion of readily available bulk ch
 emicals (e.g.\, furans) to advanced chiral intermediates (e.g.\, pyranones
 ) which in turn can be readily assembled into stereochemical complex molec
 ules of interest (e.g.\, oligosaccharides). Fundamental to our approach is
  the development of highly efficient and stereoselective routes that trans
 form\, via catalysis\, inexpensive and readily available building blocks i
 nto complex natural products and oligosaccharides and related stereoisomer
 s for further biomedical investigations.\n 
URL:https://www.imperial.ac.uk/events/99826/professor-george-a-o-doherty-no
 rtheastern-university-boston-ma/
DTSTART;TZID=Europe/London:20171031T120000
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LOCATION:United Kingdom
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